No abstract

Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-methylate histones on arginine residues. Here we show that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the macrophages. In mouse models of COPD, lung fibrosis and skin injury, reduced expression of PRMT7 associates with decreased recruitment of monocytes to the site of injury and hence less severe symptoms. Mechanistically, activation of NF-κB/RelA in monocytes induces PRMT7 transcription and consequential mono-methylation of histones at the regulatory elements of RAP1A, which leads to increased transcription of this gene that is responsible for adhesion and migration of monocytes. Persistent monocyte-derived macrophage accumulation leads to ALOX5 over-expression and accumulation of its metabolite LTB4, which triggers expression of ACSL4 a ferroptosis promoting gene in lung epithelial cells. Conclusively, inhibition of arginine mono-methylation might offer targeted intervention in monocyte-driven inflammatory conditions that lead to extensive tissue damage if left untreated.

This article evaluates the role civil society organizations play in helping noncitizen migrant workers access to social rights in Canada. The study focuses on the bilateral Canadian Seasonal Agricultural Workers Program, a temporary worker scheme that brings Mexicans to Canada to work as harvesters for a four‐to‐eight‐month period. Despite the common description of this program as “best practice,” questions are raised about the ability of workers to access citizenship rights and even limited labor protections. We draw on primary field research conducted in the province of Ontario's agricultural sector to consider how involvement of civil society state actors operating at a variety of scales—local, national, international, and the extra territorial—in a range of social justice struggles expands access to social citizenship rights for Mexican migrant workers. Este artículo evalúa el rol que juegan las organizaciones de la sociedad civil en la ayuda a los trabajadores migrantes no‐ciudadanos en el acceso a derechos sociales en Canadá. El estudio se enfoca en el Programa Bilateral Canadiense de Trabajadores Agrícolas Temporales (SAWP, por sus siglas en inglés), un esquema de trabajo temporal que lleva mexicanos a Canadá a trabajar como segadores por un periodo de entre cuatro y ocho meses. A pesar de la descripción de este programa como de una “buena política/práctica,” surgen preguntas acerca de la habilidad de los trabajadores de acceder a derechos ciudadanos y hasta de protección laboral limitada. Analizamos a partir de una investigación primaria conducida en el sector agrícola de la provincia de Ontario, considerar cómo la participación de actores estatales de la sociedad civil en una variedad de niveles—local, nacional, internacional y extraterritorial—en el ámbito de la justicia social amplía el acceso de los trabajadores migrantres mexicanos a los derechos sociales.

A method for the measurement of fast, intensity-dependent refractive-index changes with the use of a modified Sagnac ring interferometer is presented. The measurement is not degraded by slowly responding background index changes. Nonlinear refractive-index changes in an undoped silicon wafer, and in poly-bis toluene sulfonate polydiacetylene and dye-doped polymethyl methacrylate waveguides, were measured with the use of a cw mode-locked Nd:YAG laser.

Cardiac echinococcosis is a rare condition, and its manifestations are protean depending upon its site of infestation. We report a case of hydatid heart disease presenting like an acute cardiac ischemic episode associated with a rise in serum cardiac enzymes secondary to left ventricular free wall dissection caused by ruptured intramyocardial echinococcal cyst. The resultant complex cardiac anatomy was characterized fully by echocardiographic examination.