AbstrakPeningkatan pemakaian obat dengan kandungan asli untuk lebih bebas efek toksik, mudah didapat dan harga yang terjangkau telah menjadi kebutuhan masyarakat dewasa ini. Jatropha multifida, dengan kandungan bioaktif alkaloid, flavonoid, saponin, tanin, dan diterpenoid berperan dalam penyembuhan luka. Tujuan penelitian untuk mengetahui potensi ekstrak Jatropha multifida terhadap jumlah fibroblast pada proses penyembuhan aphthous ulcer atau sariawan yang sering terjadi di masyarakat. Subyek penelitian adalah 24 ekor tikus Rat norvegicus dibagi menjadi kelompok K0 (CMC-Na), P1 (JM 2,5%); P2 (JM5%), P3(JM10%). Perlukaan pada mukosa mulut tikus dengan memakai burnisher yang dipanaskan dan ekstrak J.Multifida diberikan secara topikal 2 kali sehari selama 5 hari. Tikus dikorbankan dan dibiopsi incise pada hari ke-5. Untuk melihat jumlah fibroblast dilakukan pembuatan preparat dengan pengecatan Hematoxylin Eosin. Hasil: Terdapat perbedaan jumlah fibroblast secara signifikan pada hari ke-5 di K0 (55,70), P1(69,60), P2(48,20), P3(65,53). Kesimpulan: ada perbedaan bermakna antara kelompok kontrol, P1 dan P2 dengan P3. Ektrak gel Jatropha multifida 5% paling efektif terhadap jumlah fibroblast pada proses penyembuhan mukosa mulut tikus rat norvegicus.Kata kunci : Aphthous ulcer, Jatropha multifida, fibroblast
Macrophages related with pathogen was involved the ability of Mycobacterium tuberculosis (Mtb) to developing mechanisms to prevent macrophage attacks and the aim of this study was to find the relationship between specific role of macrophages in natural immune system in tuberculosis (TB) disease. The research design of this study used literature reviews from various journals and it was accessed in Google Scholar and various medical science websites who bublessed less than 10 years. Localization of mycobacteria in granulomas form and activation of macrophages ability to kill and eliminate pathogens also the movement of M1 to M2 polarization as an important part for the host to prevent widespread tissue damage. However, the loss of the immune system suppression by M1 and Th1 molecules will give benefit to fertility development of Mtb in the environment of immunity M2 / Th2. The results of this study showed that the dynamics of macrophages in tuberculosis disease is a balance of Mtb's ability to escape from the immune system. The effectiveness of anti-TB treatment repair the immune system and eliminate Mtb.
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