SignificanceDo human societies from around the world exhibit similarities in the way that they are structured and show commonalities in the ways that they have evolved? To address these long-standing questions, we constructed a database of historical and archaeological information from 30 regions around the world over the last 10,000 years. Our analyses revealed that characteristics, such as social scale, economy, features of governance, and information systems, show strong evolutionary relationships with each other and that complexity of a society across different world regions can be meaningfully measured using a single principal component of variation. Our findings highlight the power of the sciences and humanities working together to rigorously test hypotheses about general rules that may have shaped human history.

a b s t r a c tRadiocarbon date frequency distributions and archaeological site counts are two popular proxies used to investigate prehistoric demography, following the assumption that variations in these data reflect fluctuations in the relative size and distribution of past populations. However, the two approaches are rarely applied to the same data-set and their applicability is heavily conditioned by the archaeological record in question, particularly research histories, agendas, and funding availability. In this paper we use both types of data to examine the population history of the Upper Palaeolithic hunteregatherers (~40 000e12 000 cal BP) of Southwestern France, comparing the demographic signatures generated.Both proxies produce similar signatures across the Upper Palaeolithic sequence of the region, strengthening the interpretation of relative demographic changes as the cause of the pattern. In particular, a marked population decline is seen in both datasets during the Late Gravettian (~28 000 cal BP), as well as a population increase in the Late Solutrean (~25 000 cal BP) supporting the notion that the region acted as a population refugium during the Last Glacial Maximum. Where the two proxies diverge in the demographic signatures they produce, the radiocarbon date distribution shows peaks compared to troughs in site counts; the opposite pattern expected given taphonomic issues surrounding cultural carbon. Despite differences in chronological resolution and sampling bias, our data suggest that the two proxies can be considered broadly equivalent; a finding which warrants the investigation of prehistoric demography in regions where either extensive survey data or radiometric dating programmes are unavailable. While some preliminary observations are made, the impact of changing mobility on diachronic patterns seen in both proxies remains, however, difficult to assess.

Mutations in oncogenes and tumor suppressor genes engender unique metabolic phenotypes crucial to the survival of tumor cells. EGFR signaling has been linked to the rewiring of tumor metabolism in non-small cell lung cancer (NSCLC). We have integrated the use of a functional genomics screen and metabolomics to identify metabolic vulnerabilities induced by EGFR inhibition. These studies reveal that following EGFR inhibition, EGFR-driven NSCLC cells become dependent on the urea cycle and, in particular, the urea cycle enzyme CPS1. Combining knockdown of CPS1 with EGFR inhibition further reduces cell proliferation and impedes cell-cycle progression. Profiling of the metabolome demonstrates that suppression of CPS1 potentiates the effects of EGFR inhibition on central carbon metabolism, pyrimidine biosynthesis, and arginine metabolism, coinciding with reduced glycolysis and mitochondrial respiration. We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous pyrimidines partially rescues the impairment in cell growth. Finally, we show that high expression of CPS1 in lung adenocarcinomas correlated with worse patient prognosis in publicly available databases. These data collectively reveal that NSCLC cells have a greater dependency on the urea cycle to sustain central carbon metabolism, pyrimidine biosynthesis, and arginine metabolism to meet cellular energetics upon inhibition of EGFR.Implications: Our results reveal that the urea cycle may be a novel metabolic vulnerability in the context of EGFR inhibition, providing an opportunity to develop rational combination therapies with EGFR inhibitors for the treatment of EGFRdriven NSCLC. Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): C. Pham-Danis, S.

Proponents of the Axial Age contend that parallel cultural developments between 800 and 200 BCE in what is today China, Greece, India, Iran, and Israel-Palestine constitute the global historical turning point toward modernity. The Axial Age concept is well-known and influential, but deficiencies in the historical evidence and sociological analysis available have thwarted efforts to evaluate the concept’s major global contentions. As a result, the Axial Age concept remains controversial. Seshat: Global History Databank provides new tools for examining this topic in social formations across Afro-Eurasia during the first two millennia BCE and first millennium CE, allowing scholars to empirically evaluate the varied and contrasting claims researchers have put forward. Results undercut the notion of a specific “age” of axiality limited to a specific geo-temporal localization. Critical traits offered as evidence of an axial transformation by proponents of the Axial Age concept appeared across Afro-Eurasia hundreds, and in some cases thousands, of years prior to the proposed Axial Age. Our analysis raises important questions for future evaluations of this period and points the way toward empirically-led, historical-sociological investigations of the ideological and institutional foundations of complex societies.

Proponents of the Axial Age contend that parallel cultural developments between 800 and 200 BCE in what is today China, Greece, India, Iran, and Israel-Palestine constitute the global historical turning point towards modernity. While the Axial Age concept is well-known and influential, deficiencies in the historical evidence and sociological analysis available have thwarted efforts to evaluate the Axial Age concept’s major global contentions. As a result, the Axial Age concept remains controversial. Seshat: Global History Databank provides new tools for examining this topic in social formations across Afro-Eurasia during the first two millennia BCE and first millennium CE, allowing scholars to empirically evaluate the many varied— and contrasting—claims put forward about this period. Our systematic investigation undercuts the notion of a specific 'age' of axiality limited to a specific geo-temporal localization. Critical traits offered as evidence of an axial transformation by proponents of the Axial Age concept are shown to have appeared across Afro-Eurasia hundreds and in some cases thousands of years prior to the proposed Axial Age. Our analysis raises important questions for future evaluations of this period and points the way towards empirically-led, historical-sociological investigations of the ideological and institutional foundations of complex societies.

Racial tension motivates strife and violence in the metropolitan Detroit, Michigan, area. The purpose of this study was to determine the effectiveness of a collaborative partnership, the Cultural Awareness Consortium (CAC), in making a positive impact on the attitudes of a group of diverse high school students regarding multicultural relations. The two theoretical frameworks guiding this study were Allport’s intergroup contact theory and intercultural competence theory originating from International Education and International Studies. The research questions concerned whether attending the CAC for 4 months, the treatment, changed students’ attitudes on multicultural relations, and whether a student’s gender or ethnicity was a predictor of changes in these attitudes. A single group, pre-experimental design with data collection from two administrations of the Student Multicultural Relations Survey was used in the study. Fifty-four students completed the survey, which yielded four multicultural relations scales (dependent variables), eight single-item attitudinal variables on multicultural issues, and two demographic variables (independent variables), and inferential analysis included <em>t </em>tests and multiple regression. According to study results, students’ attitudes on multicultural relations had changed significantly, and students talked to and mixed with students from different cultural backgrounds more after the treatment. Educational institutions providing experiences like the CAC can make a positive impact on students’ attitudes on multicultural relations. This can lead to positive social change as students increase their acceptance of others and take those attitudes and values with them into the workforce after they graduate, serving as role models of acceptance for their peers.

This article reports the results of a collaborative research project that aims to estimate agricultural productivities of the past societies in the Seshat World Sample-30. We focus on 30 Natural Geographic Areas (NGAs) distributed over 10 major world regions (Europe, Africa, Southwest Asia, South Asia, Southeast Asia, East Asia, Central Eurasia, North America, South America, and Oceania). The conceptual framework that we use to obtain these estimates combines the influences of the production technologies (and how they change with time), climate change, and effects of artificial selection into a Relative Yield Coefficient, indicating how agricultural productivity changed over time in each NGA between the Neolithic and Industrial Revolutions. We then use estimates of historical yield in an NGA to translate the Relative Yield Coefficient into an Estimated Yield (tons per hectare per year) trajectory. We tested the proposed methodology in two ways. For eight NGAs, in which we had more than one historical yield estimate, we used the earliest estimate to anchor the trajectory and compared the ensuing trajectory to the remaining estimates. We also compared the end points of the estimated NGA trajectories to the earliest (the 1960s decade) FAO data on crop productivities in the modern countries encompassing Seshat NGAs.

The role of the environment in shaping agricultural origins is still not fully understood, despite a century of debate on this topic. Comparison of the expected prevalence of a resource in the landscape with actual archaeological presence of the same resource can provide a metric for assessing resource choice in prehistory. However, the palaeoenvironmental data that would allow resource choice to be evaluated in this way are rarely available. Species Distribution Modelling (SDM) techniques allow independent