A water soluble extract from the bark of the Samoan medicinal plant Alphitonia zizyphoides A. Gray (Rhamnaceae), enhances the plating efficiency in vitro of lymphoid cell lines as well as the survival of bone marrow cells and normal T and B lymphocytes. Furthermore, the inclusion of bark-extract into culture media enhances the cloning efficiency of a T-hybridoma cell line by more than 30 times at otherwise unsuitably low serum concentrations, but does not completely substitute for serum. The enhanced growth of a B-cell hybridoma is also paralleled by an increased production of monoclonal antibodies in cultures containing low cell densities.
Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. -The structure of title compound (I) is determined by mass spectrometry in combination with oneand two-dimensional NMR investigations. -(ANDERSSON DUNSTAN, C.; LIU, B.; WELCH, C. J.; PERERA, P.; BOHLIN, L.; Phytochemistry 48 (1998) 3, 495-497; Dep. Org. Pharm. Chem., Biomed. Cent., Uppsala Univ., S-751 23 Uppsala, Swed.; EN)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.