The interactions between sulfadiazine (SDZ), a sulfonamide antibiotic, and clinoptilolite, a hydrophilic zeolite, were investigated under batch experimental conditions. The uptake of SDZ on the zeolite followed a linear sorption isotherm under neutral pH conditions. Higher SDZ uptake on the zeolite was observed when solution pH was below the pK a1 or above the pK a2 values of SDZ, while minimal SDZ uptake was observed when the solution pH was between the pK a1 and pK a2 values of SDZ. These observations suggested that hydrophobic interaction between SDZ and the zeolite was minimal due to the hydrophilic nature of the substrate. Electrostatic interactions and ion bridging were attributed to the elevated SDZ uptake under low and high pH conditions. As SDZ had a low K OW value, the hydrophilic nature of the substrate prevented extensive uptake of SDZ, which could contribute to its extensive detection in the environment, including surface water and wastewater.
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