An unexpectedly high rate of virological treatment failure of protease inhibitor therapy was found in an unselected cohort of HIV-infected patients. Response to antiretroviral combination therapy in normal clinical practice may considerably differ from results of randomized clinical trials. Further studies are warranted to find optimal treatment strategies for both initial and salvage therapy.
The industrial past has become an inescapable and fundamental component of the identity of the Ruhr region. Throughout the twentieth century the Ruhr acquired a diverse public self-perception—incorporating multiculturalism, football, nationalism, urbanity, and nature—that was strongly imbued by images of the industrial past. Over recent decades, representations of the Ruhr’s industrial heritage have been driven by a desire to build the future of the region on a proud sense of its past. However, there have also been signs of an increasing touristification and commercialization of industrial heritage that is sometimes presented in a self-congratulatory way. Development of a critical “historical culture” involving the region’s industrial past therefore remains a constant challenge.
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