The presence of variable degrees of cognitive impairment, extending from severe mental retardation to specific deficits, in patients with dystrophinopathies is a well-recognized problem. However, molecular basis underlying mental retardation and its severity remain poorly understood and still a matter of debate. Here, we report one of the largest study based on the comparison of clinical, cognitive, molecular and expression data in a large cohort of 81 patients affected with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) bearing mutations predicted to affect either all dystrophin products, including Dp71 or all dystrophin products, except Dp71. In addition to the consistent data defining molecular basis underlying mental retardation in DMD, we show that BMD patients with MR have mutations that significantly affect Dp71 expression or with mutations located in exons 75 and 76. We also show that mutations upstream to exon 62, with DMD phenotype, predicted to lead to a loss-of-function of all dystrophin products, except Dp71 isoform, are associated, predominantly, with normal or borderline cognitive performances. Altogether, these reliable phenotype-genotype correlations in combination with Dp71 mRNA and protein expression studies, strongly indicate that loss-of-function of all dystrophin products is systematically associated with severe form of MR, and Dp71 deficit is a factor that contributes in the severity of MR and may account for a shift of 2 SD downward of the intelligence quotient.

Objectives. -The goal of this paper is to present the validation process of the French BFI (BFI-Fr) on a large student sample to verify psychometric properties, including factor structure and internal reliability and to show that the scales possess the necessary convergent and discriminant validity with the NEO-PI-R. Study 1: internal consistency and intercultural comparisonMaterials and method. -2 499 students were included (women 69%; mean age 20.2 years old, SD=2.21, between 15 and 46 years). The 45 items of the BFI-Fr were filled out anonymously by the students at the university.Results and discussion. -A factorial analysis using principal components was performed on the student answers (raw data) and resulted in a five-factor varimax- Normality of the distribution factors was verified before comparing the scores of French students with those of American and Spanish students. Mean scores and standard deviations were very similar in the three countries. As in previous research, gender differences in personality were found: females had higher scores (p <.001) for N, A, and C Study 2: convergent and discriminant validation with the NEO-PI-RThe goal of study 2 was to compare the BFI-Fr with the NEO-PI-R. General discussion and conclusion. -All three studies demonstrate that the BFI-Fr is a valid, powerful yet very efficient tool, as are the original English version and the other translations. The much longer NEO-PI-R remains the instrument of choice. Psychiatrists, psychologists, and researchers can now make use of another inventory in French to measure the Big Five which has the advantages of being simple, robust, reliable, and economical (5 to 10 minutes to complete).

Objective: The concept of food addiction has recently been proposed by applying the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, criteria for substance dependence to eating behaviour. Food addiction has received increased attention given that it may play a role in binge eating, eating disorders, and the recent increase in obesity prevalence. Currently, there is no psychometrically sound tool for assessing food addiction in French. Our study aimed to test the psychometric properties of a French version of the Yale Food Addiction Scale (YFAS) by establishing its factor structure and construct validity in a nonclinical population.Method: A total of 553 participants were assessed for food addiction (French version of the YFAS) and binge eating behaviour (Bulimic Investigatory Test Edinburgh and Binge Eating Scale). We tested the scale's factor structure (factor analysis for dichotomous data based on tetrachoric correlation coefficients), internal consistency, and construct validity with measures of binge eating. Results:Our results supported a 1-factor structure, which accounted for 54.1% of the variance. This tool had adequate reliability and high construct validity with measures of binge eating in this population, both in its diagnosis and symptom count version. A 2-factor structure explained an additional 9.1% of the variance, and could differentiate between patients with high, compared with low, levels of insight regarding addiction symptoms. Conclusions:In our study, we validated a psychometrically sound French version of the YFAS, both in its symptom count and diagnostic version. Future studies should validate this tool in clinical samples. W W WValidation de la version française de l'échelle de dépendance alimentaire de Yale : un examen de sa structure factorielle, de sa fiabilité, et de la validité du construct dans un échantillon non clinique Objectif : La dépendance alimentaire est un concept qui a été récemment proposé en appliquant au comportement alimentaire les critères de dépendance à une substance du Manuel diagnostique et statistique des troubles mentaux, 4e édition, révisé. La dépendance

Lower QOL scores were more strongly associated with variables related to the individual's premorbid psychological characteristics and the manner in which this individual copes with the cancer (e.g., depression, personality, and coping) than to cancer-related variables (e.g., treatment types and cancer severity). Copyright © 2015 John Wiley & Sons, Ltd.

Objective: The Yale Food Addiction Scale (YFAS) is the only questionnaire that assesses food addiction (FA) based on substance dependence criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, Text Revision. Following recent updating of addiction criteria, a new DSM-5 version (YFAS 2.0) has been developed. Our study tested the psychometric properties of the French YFAS 2.0 in a nonclinical population. Method:We assessed 330 nonclinical participants for FA (French YFAS 2.0), eating behaviour, and eating disorder (Binge Eating Scale, Emotional Overeating Questionnaire, Three-Factor Eating Questionnaire-R18, Questionnaire on Eating and Weight Patterns-Revised, Eating Disorder Diagnostic Scale). We tested the scale's factor structure (confirmatory factor analysis based on 11 diagnostic criteria), internal consistency, and construct and incremental validity.Results: Prevalence of FA was 8.2%. Our results supported a 1-factor structure similar to the US version. In both its diagnostic and symptom count versions, the YFAS 2.0 had good internal consistency (Kuder-Richardson alpha was 0.83) and was associated with body mass index (BMI), binge eating, uncontrolled and emotional eating, binge eating disorder, and cognitive restraint. FA predicted BMI above and beyond binge eating frequency. Females had a higher prevalence of FA than males but not more FA symptoms. Conclusions:We validated a psychometrically sound French version of the YFAS 2.0 in a nonclinical population, in both its symptom count and diagnostic versions. Future studies should investigate psychometric properties of this questionnaire in clinical populations potentially at risk for FA (that is, patients with obesity, diabetes, hypertension, or other metabolic syndrome risk factors). Abré géObjectif : L'échelle d'addiction à l'alimentation de Yale (YFAS) est le seul questionnaire qui évalue l'addiction à l'alimentation (AA) selon les critères de dépendance aux substances du Manuel diagnostique et statistique des troubles mentaux (DSM), 4 e édition,

Aims and objectivesThe main aim of this study was to investigate the indirect effects of emotional dissonance and workload on presenteeism and emotional exhaustion through sleep quality and relaxation.BackgroundNumerous investigations have found that job demands are related to employees' health and behaviours, but additional studies are needed among nurse samples. Specifically, little is known about the relationships between nurses' emotional dissonance and workload on one hand, and presenteeism and emotional exhaustion on the other hand. Moreover, research is needed to further explore the psychological mechanisms underlying these relationships.DesignWe used a cross‐sectional design. Our study was carried out between October 2015–February 2016. Precisely, we asked nurses from various French healthcare centres to fill out a questionnaire survey. We ensured to meticulously follow the STROBE guidelines for cross‐sectional research in designing and reporting this study.MethodAn empirical study with a sample of 378 nurses was conducted.ResultsIn line with our hypotheses, our findings revealed that emotional dissonance and workload were negatively linked to sleep quality and relaxation, which were, in turn, related to lower levels of presenteeism and emotional exhaustion. Workload and emotional dissonance were also directly and positively related to emotional exhaustion, while emotional dissonance was associated with higher levels of presenteeism. Finally, the indirect effects of emotional dissonance and workload on emotional exhaustion through sleep quality as well as the indirect effects of emotional dissonance on emotional exhaustion through relaxation were significant and positive.ConclusionsOverall, our results provide insight into the effects of emotional dissonance and workload on presenteeism and emotional exhaustion through recovery processes.Relevance to clinical practiceThe present findings have some practical implications for reducing nurses' emotional exhaustion and presenteeism. Specifically, managers and organisations should try to design and craft jobs to decrease the presence of negative work characteristics (i.e., workload and emotional dissonance). Our results also suggest that recovery processes may be important factors to focus on.

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Systematic screening for and treatment of FA symptoms before obesity surgery is critical because FA symptoms are prevalent and associated with poorer psychosocial outcome.