Metal(H2O2) complexes have been implicated in kinetic and computational studies but have never been observed. Accordingly, H2O2 has been described as a very weak ligand. We report the first metal(H2O2) adduct, which is made possible by incorporating intramolecular hydrogen-bonding interactions with bound H2O2. This Zn(II)(H2O2) complex decays in solution by a second-order process that is slow enough to enable characterization of this species by X-ray crystallography. This report speaks to the intermediacy of metal(H2O2) adducts in chemistry and biology and opens the door to exploration of these species in oxidation catalysis.

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CoII complexes bearing sulfonamido ligands derived from tris(2-aminoethyl)amine (H6tren) assemble into complex architectures in the presence of Group II ions through interactions between the Group II ion and the sulfonyl oxygens.

M(H2 O2 ) adducts have been postulated as intermediates in biological and industrial processes; however, only one observable M(H2 O2 ) adduct has been reported, where M is redox-inactive zinc. Herein, direct solution-phase detection of an M(H2 O2 ) adduct with a redox-active metal, cobalt(II), is described. This Co(II) (H2 O2 ) compound is made observable by incorporating second-sphere hydrogen-bonding interactions between bound H2 O2 and the supporting ligand, a trianionic trisulfonamido ligand. Thermodynamics of H2 O2 binding and decay kinetics of the Co(II) (H2 O2 ) species are described, as well as the reaction of this Co(II) (H2 O2 ) species with Group 2 cations.

IgG antibody-transporter conjugates enable intracellular uptake of biologically active IgG antibodies that inhibit viral mediated syncytia formation in respiratory syncytial virus green fluorescent protein (RSV-GFP) infected human epithelial cells (HEp-2).