METHODS.ment. A better response rate to second-line chemotherapy was observed in patients with the following features: 1) chemotherapy free time (time between onset of metastatic disease and initiation of first-line) õ 12 months (P Å 0.03); 2) complete response to first-line chemotherapy (P Å 0.013); 3) response duration to first-line chemotherapy ú 14 months (P Å 0.0001); 4) progression free interval (time between end of first-line treatment and initiation of second-line chemotherapy) ú 11 months (P Å 0.0001); 5) performance status at second-line treatment õ 2 (P Å 0.04); 6) tumor index at second-line chemotherapy õ 4 (P Å 0.05); and 7) treatment with an anthracycline-containing second-line regimen (P Å 0.03). In multivariate analysis, only progression free interval was identified as being associated with response rate to second-line chemotherapy (P Å 0.0001).
CONCLUSIONS.Retained chemosensitivity appeared to be an important characteristic in patients responding to second-line chemotherapy.
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