1) Analyses of surface P wave configuration proved to be reasonably good in differentiating right atrial from left atrial tachycardia foci. 2) Leads II, III and aVF were helpful in providing clues for differentiating superior from inferior foci.

Flexible intramedullary nails are now routinely used for stabilization of pediatric femur fractures. Few data are available regarding patients' postoperative range of motion, weight-bearing status, activity levels, use of immobilization, and radiographic leg length discrepancy measured via routine scanograms. Patients who underwent placement of flexible intramedullary nails for a pediatric femur fracture at a single institution from 1998 to 2003 were identified retrospectively. Ninety-one patients were identified with 94 femur fractures. The complication rate was 17% for the 94 fractures, with 8 patients requiring an unplanned return to surgery. The complication rate was significantly higher for patients aged 10 years or older (34%) as compared with that for younger patients (9%). Average time to full weight bearing was 10 weeks, time to radiographic union averaged 10.7 weeks, and time to return to preoperative level of activity averaged 4.9 months. Immediate postoperative weight bearing status was nonweight bearing in 57%. Immobilization or support was used postoperatively in 60% of the patients. Postoperatively, patients had minimal loss of range of motion in hip internal and external rotation and knee extension. Hip and knee flexion rapidly improved postoperatively with an average loss of hip flexion of 0 degree by 3 months and an average loss of knee flexion of 4 degrees by 6 months. Postoperatively, limb length discrepancy was greater than 1 cm in 7 patients at 6 months, 11 patients at 12 months, 3 patients at 18 months, and 2 patients at 2 years. Two patients had persistent limb length discrepancy of greater than 2 cm, but only one patient required an epiphysiodesis for his limb length inequality. Although the end results are favorable, complications are relatively frequent, particularly in older children.

No abstract

Recently, deep brain stimulation (DBS) has been evaluated as an experimental therapy for treatment-resistant depression. Although there have been encouraging results in open-label trials, about half of the patients fail to achieve meaningful benefit. Although progress has been made in understanding the neurobiology of MDD, the ability to characterize differences in brain dynamics between those who do and do not benefit from DBS is lacking. In this study, we investigated EEG resting-state data recorded from 12 patients that have undergone DBS surgery. Of those, six patients were classified as responders to DBS, defined as an improvement of 50% or more on the 17-item Hamilton Rating Scale for Depression (HAMD-17). We compared hemispheric frontal theta and parietal alpha power asymmetry and synchronization asymmetry between responders and non-responders. Hemispheric power asymmetry showed statistically significant differences between responders and non-responders with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry was characterized by an increase in frontal theta in the right hemisphere relative to the left combined with an increase in parietal alpha in the left hemisphere relative to the right in non-responders compared with responders. Hemispheric mean synchronization asymmetry showed a statistically significant difference between responders and non-responders in the theta band, with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry resulted from an increase in frontal synchronization in the right hemisphere relative to the left combined with an increase in parietal synchronization in the left hemisphere relative to the right in non-responders compared with responders. Connectivity diagrams revealed long-range differences in frontal/central-parietal connectivity between the two groups in the theta band. This pattern was observed irrespective of whether EEG data were collected with active DBS or with the DBS stimulation turned off, suggesting stable functional and possibly structural modifications that may be attributed to plasticity.