The polyphenol epigallocatechin-3-gallate (EGCG) in combination with doxorubicin (Dox) exhibits a synergistic activity in blocking the growth and colonyforming ability of human prostate cell lines in vitro. EGCG has been found to disrupt the mitochondrial membrane potential, induce vesiculation of mitochondria, and induce elevated poly (ADP-ribose) polymerase (PARP) cleavage and apoptosis. EGCG in combination with low levels of Dox had a synergistic effect in blocking tumor cell growth. Epidemiological studies have suggested a protective effect of tea consumption against human cancers of the breast, cervix, colon and rectum, gallbladder, liver, lung, nasopharynx, pancreas, prostate, stomach, ovary, and uterus. [1][2][3][4] Recent epidemiological studies have demonstrated the cancer preventive properties of green tea polyphenols in prostate cancer. 2,5,6 Animal tumor modeling studies using green tea, green tea leaves, green tea extracts, polyphenol mixtures, green tea catechin mixtures, and the individual catechins have demonstrated chemopreventive efficacy in several cancers. Using the Transgenic adenocarcinoma of the mouse prostate (TRAMP) mouse model for prostate cancer, Gupta et al 7 showed that a polyphenol extract delivered by gavage (500 mg/kg/day) partially delayed the onset of prostate cancer and inhibited prostate cancer growth to increase mouse survival rates. Polyphenol consumption caused significant apoptosis of the tumor cells, which possibly resulted in reduced dissemination of cancer cells, thereby causing inhibition of tumor development, progression, and metastasis. However, a similar animal model study with epigallocatechin gallate (EGCG; ie, purified from polyphenols) added to the drinking water only slightly reduced the incidence of prostate cancer and tumor progression.