Cold-preserved allografts seeded with autologous Schwann cells were well-tolerated in unrelated recipients and supported significant regeneration across 6-cm peripheral nerve defects. Use of cold-preserved allogeneic nerve tissue supplemented with autogenous Schwann cells poses a potentially safe and effective alternative to the use of autologous tissue in the reconstruction of extensive nerve injuries.
These data suggest that enhancement of FK-506's neuroregenerative effect is enhanced when administered before nerve injury such as when performing elective surgery.
A novel multispectral, autofluorescence and reflectance tool has been developed to improve differentiation of lesions from normal tissues. We report excellent results on a multicenter referral cohort of 120 patients, and the screening implications.
BackgroundMore than 34,000 Americans will be diagnosed with oral or pharyngeal cancer this year, and only 50% of those diagnosed will still be alive in 5 years. These high mortality rates are a direct result of only 30% of oral cancer cases being detected at an early stage [1]. Indeed, despite the easy accessibility of the oral cavity to examination, most patients present with advanced disease, when the morbidity and mortality associated to the disease are higher.Significantly, more than 80% of all cases of oral squamous cell carcinoma are preceded by visible premalignant lesions, leukoplakia or erithroplakia, which can then evolve to dysplasia or cancer. However, while a high percentage of lesions with high grade dysplasia progress to cancer, most leukoplakia lesions have only mild to moderate dysplasia, and are less likely to result in cancer [2]. Thus there is significant need for new technologies which facilitate oral cancer screening and diagnosis, and which can aid the clininician in directing appropiate treatment.Autofluorescence imaging of oral premalignant lesions using wide field fluorescence and reflectance can improve contrast of relevant features, and thus has been used to develop a rapid, non-invasively method to identify malignant oral lesions. This method relies in the optical imaging of the morphological and biochemical changes associated with neoplastic tranfrormation [3]. Inded, Roblyer et al. report that autofluorescence excited at 405 nm provides optimal contrast for discriminating normal from premalignant and malignant changes [4,5]. We have developed a diagnostic device capable of multispectral imaging at these wavelengths.
Results
Identafi ® 3000 ultra: a multispectral imaging tool for oral cancer diagnosisWe developed a system composed of: a battery powered, multispectral handpiece, disposable sheath with #4 dental mirror, shown in figure 1. The multispectral handpiece provides a white light for conventional oral exam, a violet light at 405 nm for optimal-contrast autofluorescence visualization, and a green-amber light (dominant 545nm) for independent visualization highlighting vascular patterns and blood-rich areas.OSA / BIOMED/DH 2010 BSuD105.pdf
The year 2006 marked the 100th anniversary of the publication of Eugene Apert's article, De l'acrocephalosyndactylie in the Bulletin de la Société des médecins des hôspitaux de Paris. During the last century, much progress has been made in the understanding and treatment of this condition. A translation of Apert's original article is provided as is an overview of what has been learned during the last 100 years and what the future treatment of this condition may be.
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