Consumers and academics are paying attention to affordable Virtual Reality (VR) (VR) remedies such as the Sony Entertainment VR, Vive VR and Oculus VR, including the Mixed-Reality Interface (MRITF) such as Hololens, which suggests it may be the next big thing in technical advancement. Nevertheless, VR has a wide history: the ideology of the remedy was initiated in 1960s, and commercialized toolkit for VR in the 1960s introduced in 1980s. This paper starts with the analysis of the development from VR to Augmented Reality (AR). We conclude by evaluating implications that MRITF, AR and VR will be capable of succeeding in the scientific disciplines, incorporating the human interaction as evident in the advent of cellular devices, altered social engagement, and understanding among individuals, as occurred with the emergence of smartphones.