No abstract

Objectives Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight. Results Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs − 0.45 ± 1.47, p = 0.045) and a greater proportion of current obesity (42% vs 2.5%, p < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 34.77, 95%CI 1.814–666.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.

Objectives: Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight.Results: Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs -0.45 ± 1.47, P = 0.045) and a greater proportion of current obesity (42% vs 2.5%, P < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 20.5, 95%CI 1.07-391.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, so-called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.

Objective: To identify the risk factors and describe the outcomes of patients who developed acute kidney injury (AKI)during treatment for myeloid leukemia of Down syndrome (ML-DS).Material and Methods: The medical records of 23 Down syndrome patients under the age of 15 who had been diagnosedwith acute myeloid leukemia (AML) and were being treated at a major tertiary care referral facility in Southern Thailandwere reviewed. The identification of factors associated with AKI was done using logistic regression. The Kaplan-Meiermethod was used to calculate survival probabilities.Results: Eight (34.8%) patients developed AKI during their course of chemotherapy with a median time from the firstvisit to the AKI event of 1.1 (IQR 0.7, 3.1) months. Higher levels of blast cells (OR: 1.19, 95% CI: 1.05-1.98) and septicshock during the course of chemotherapy (OR: 621.1, 95% CI: 2.40-Inf.) were independently associated with AKI. The1-year overall survival rate was 26.1%. The median survival times among those who developed AKI and those who didnot were 1.94 and 10.7 months, respectively.Conclusion: About one-third of the cases with ML-DS in our cohort developed AKI during the course of chemotherapy.The risk factors of AKI were higher peripheral blast count and septic shock during chemotherapy.