Ubiquitin Conjugating Enzyme 2C (UBE2C) is an emerging target gene for tumor progression. However, the tumorigenic effect and mechanism of UBE2C in adrenocortical carcinoma (ACC) remains unclear. Systematic investigation of the tumorigenic effect of UBE2C may help in understanding its prognostic value in adrenocortical carcinoma. First, we exploited the intersection on DFS-related genes, OS-related genes, highly expressed genes in adrenocortical carcinoma as well as differentially expressed genes (DEGs) between tumor and normal, and then obtained 20 candidate genes. UBE2C was identified to be the most significant DEG between tumor and normal. It is confirmed that high expression of UBE2C was strongly associated with poor prognosis in patients with ACC by analyzing RNA-seq data of ACC obtained from the Cancer Genome Atlas (TCGA) database implemented by ACLBI Web-based Tools. UBE2C expression could also promote m6A modification and stemness in ACC. We found that UBE2C expression is positively associated with the expression of CDC20, CDK1, and CCNA2 using ACLBI Web-based Tools, indicated the hyperactive cell cycle progression present in ACC with high UBE2C expression. In addition, UBE2C knockdown could significantly inhibit the proliferation, migration, invasion, EMT of adrenocortical carcinoma cells as well as the cell cycle progression in vitro. Notably, pan-cancer analysis also identified UBE2C as an oncogene in various tumors. Taken together, UBE2C was strongly associated with poor prognosis of patients with ACC by promoting cell cycle progression and EMT. This study provides a new theoretical basis for the development of UBE2C as a molecular target for the treatment of ACC.
Nursing staff are the largest number of employees in hospitals and the high turnover rate is a global problem, which is also a critical issue faced by many hospitals in Taiwan. Therefore, the purpose of this study is to explore the factors affecting the job turnover of nursing staff and to propose suggestions to reduce job turnover. The results showed that among demographic variables, all variables except the affiliated unit were significantly positively or negatively related to job turnover intention. In the job characteristic analysis, it was found that job structure, repetitiveness of the job, the participation of nursing staff in job decisions, and compassionate leadership style were the antecedent variables affecting the intention to leave. Among organizational factors, colleague rapport was an antecedent variable to the intention to leave. Fairness of distribution, opportunity of in-service education, and colleague rapport added to job satisfaction to decrease the intention to leave. When using job performance as a mediation variable, this study found that promotion opportunity, fairness of distribution, and opportunity of in-service education could not affect the intention to leave through job performance. This study also found that the external job opportunities variable could be through a mediation variable, job satisfaction or job performance, which in turn affected the intention to leave. Several suggestions were proposed for top hospital management personnel, such as management by participation, planning a clear job structure, job rotation and job enrichment, and establishing a good working atmosphere and working environment to reduce job turnover.
BackgroundHere provides a complementary treatment, acupressure at the Qiu acupoint, a novel acupoint, which potentially alleviates renal colic.Materials and methods90 patients were included in this study. Acupressure-group patients (n = 46) were administered acupressure at the Qiu acupoint following a preset protocol. Parecoxib sodium-group patients (n = 44) were administered parecoxib sodium (40 mg) (via the direct intravenous route). The visual analog scale (VAS) was used to evaluate pain intensity at baseline and at 1, 5, 10, 20, 30, and 120 min after initiating the intervention. Linear mixed effects model was performed to detect the rate of decrease of VAS per time and their covariant effect on the efficacy of acupressure.ResultsNo significant statistical differences in baseline data and VAS scores were observed. The acupressure group obtained lower VAS scores at the 1st, 5th, 10th, and 20th minute than the parecoxib sodium group after initiating the intervention (mean: 4.33 vs. 7.61, mean difference (MD): 3.29, 95% CI: 0.23, 2.84; mean: 2.65 vs. 7.61, MD: 4.96, 95% CI: 4.44, 5.49; mean: 1.63 vs. 6.59, MD: 4.96, 95% CI: 4.48, 5.44; mean: 1.26 vs. 3.64 MD: 2.38, 95% CI: 1.87, 2.88; P < 0.05). The markedly effective rate was similar between the two groups. The linear mixed effects model demonstrated that acupressure at the Qiu point was significantly faster than parecoxib sodium in decreasing VAS scores with an estimate of –2.05 (95% CI: –2.51, –1.59, p = 0.000), especially within 10 minutes with an estimate of 0.18 (95% CI: 0.12, 0.25, p = 0.000).ConclusionAcupressure at the Qiu acupoint is significantly faster than parecoxib sodium in decreasing VAS scores within 10 minutes.Clinical trial registrationhttp://www.chictr.org.cn/, identifier 2100047168.
Tsunami disasters have frequently occurred in recent years. More and more researchers are focusing on this topic. To investi-gate the tsunami bore impact mechanism on a container model, a multi-functional slope-changing tsunami flume is built in this study. To simulate a tsunami bore, a dam-break wave was generated by a free-falling gate in a reservoir. A needle water level gauge and a high-speed camera were used to measure the tsunami wave heights and velocities for different storage water levels in the test flume, and the corresponding Froude numbers of tsunami waves were also calculated. The factors af-fecting the movement distance of the tsunami wave impacting the container model are explored in this experiment, and the results show that the movement distance is positively correlated with the storage water level, and negatively correlated with the container density and the coast slope.
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