Background: Human immuno-deficiency virus (HIV)-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy (HIVAN). HIV peptides rather than infection may be more important in pathogenesis of HIVAN. Much has been learnt about the pathogenesis and treatment of HIV-associated renal diseases because of the development of animal models and the molecular evaluation of clinical samples.Methods: We studied 90 consecutive patients with HIV and allocated them into 3 groups, each containing 30 patients on the basis of their CD4 counts. Then each group was divided into two subgroups, X and Y on the basis of whether they received anti-retroviral treatment (HAART) or not. Subgroup X received HAART and subgroup Y did not received HAART.Results: There was male preponderance (M: F=5.4: 1). Microalbuminuria, increased serum creatinine and decreased GFR was highest among HIV patients having CD4 count below 200 as compared to those having CD4 count of 200-350 and above 350.Conclusions: Our study demonstrates that both proteinuria and HIVAN are common in HIV infected patients. Proteinuria and glomerular filtration rate have a negative correlation with the CD4 count.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.