Once considered as mere curiosities, acyl metalloids are now recognized for their useful enabling in chemical synthesis. This perspective considers the reactivity displayed by acylboron, -silicon, -germanium, and tellurium species....
Conjugated
polymers have received widespread interest as optoelectronic
materials. Recently, these macromolecules have been adopted for biologically
relevant applications, such as sensors, imaging agents, and drug delivery
vectors. A major limitation of the chemistry used to prepare these
classes of compounds is that the resultant polymers themselves are
not tolerant to water or are not inherently water-soluble. For example,
the most controlled method of conjugated polymer synthesis, the Kumada
catalyst transfer polymerization (KCTP), requires stringent drying
of monomers, catalysts, and other reagents. Here, we describe an approach
to use a water-scavenging Grignard reagent to alleviate many of the
shortcomings that currently hinder the synthesis of water-soluble
conjugated polymers. This method shows improved polymerization performance
in both traditional conjugated polymer synthesis as well as more challenging
syntheses of polar hygroscopic polymers that are of interest for biological
applications.
Sodium
cyanoborohydride-derived N-alkylnitriliumboranes
were found to be versatile precursors for the synthesis of novel boron-containing
heterocycles. The reaction between N-alkylnitriliumboranes
and 2-aminopyridines, imidazoles, oxazoles, or isoxazoles leads to
the incorporation of the [B–C] motif into a five-membered boramidine,
which exists as a mixture of Z and E isomers. The resulting heterocycles are blue fluorescent in both
the solid state and in solution with ca. 2700–8400 cm–1 Stokes shifts and quantum yields in the 65–74% range in water
and in the 42–84% range in organic solvents. The combination
of photophysical properties, structural tunability, stability, and
solubility in various media is expected to find application in a range
of disciplines.
Here we demonstrate an approach to graft bis-(heteroaryl)-containing motifs into ring structures. The process occurs by redirecting a previously reported oxadiazole-forming reaction towards a pyrazole-forming process affording pyrazolyl-azole containing molecules. Through the use of (N-isocyan-[a] C.
A new boron-containing heterocyclic scaffold – borindolizine – is reported as a new heterocyclic scaffold with broadly tunable fluorescence and a high Stokes shift. Two classes of emitters were synthesized through rational scaffold changes resulting in blue-emitting carboxyborindolizines (λmax,em = 431 – 459 nm) and green emitting aryl borindolizines (λmax,em = 488 – 519 nm). Experimental structure-emission trends were used to validate a computational spectral prediction model and subsequently used to design a red-emissive fluorophoric scaffold. A red-emissive (λmax,abs = 370 nm, λmax,em = 635 nm) isoquinolyl borinidolizine was synthesized in excellent agreement with the theoretical emission (λmax,em = 621 nm). These results establish borindolizine as a highly attractive class of fluorescent heterocycle with a highly tunable emission, allowing for custom fluorophore synthesis.
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