Biaryl and indole units are important structural motifs in several
bioactive molecules and functional materials. We have accomplished
straightforward access to C2-biarylated indole derivatives through
palladium-catalyzed C–H activation strategy with a broad range
of substrate scope in yields of 24 to 92%. Besides, the UV/visible
absorption and fluorescence properties of the ensuing products were
explored. The calculated higher dihedral angle and rotational barrier
values for the selected C2-biarylated indoles show that these compounds
may display atropisomerism at room temperature.
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