We have reported an efficient and benign approach of HCl·DMPU mediated nitrile synthesis from readily available starting materials. The procedure is operationally simple, has a broad substrate scope and the products are obtained in very good yields.

Diazenes are valuable compounds that have found broad applicability because of their optical and biological properties. We report the synthesis of alkylaryldiazenes via formal, photoredox-catalyzed, deformylative C–N bond formation. The procedure employs dihydropyridines for the generation of alkyl radicals, which are then trapped by diazonium salts and reduced to the corresponding diazenes. Control experiments were performed to confirm the involvement of radicals in the mechanism. The reaction can be carried out at room temperature and employs readily available reagents; the mild conditions allowed the use of highly functionalized substrates. There was no observed tautomerization of the diazenes to the corresponding arylhydrazones.

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A schematic of encapsulation of hemoglobin within Bio:CaRGOS formulations is summarized in the graphic, demonstrating sol–gel encapsulation as a method to stabilize hemoglobin, followed by an efficient hemoglobin release using polyethylene glycol (PEG).

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Schematic of ctDNA encapsulation in BioCaRGOS followed by release using invert syringe filtration to eliminate silica interference and enhance the biocompatibility of BioCaRGOS in ddPCR is shown.

Storage of biospecimens in their near native environment at room temperature can have a transformative global impact, however, this remains an arduous challenge to date due to the rapid degradation of biospecimens over time.