As deep learning is showing unprecedented success in medical image analysis tasks, the lack of sufficient medical data is emerging as a critical problem. While recent attempts to solve the limited data problem using Generative Adversarial Networks (GAN) have been successful in generating realistic images with diversity, most of them are based on image-to-image translation and thus require extensive datasets from different domains. Here, we propose a novel model that can successfully generate 3D brain MRI data from random vectors by learning the data distribution. Our 3D GAN model solves both image blurriness and mode collapse problems by leveraging α-GAN that combines the advantages of Variational Auto-Encoder (VAE) and GAN with an additional code discriminator network. We also use the Wasserstein GAN with Gradient Penalty (WGAN-GP) loss to lower the training instability. To demonstrate the effectiveness of our model, we generate new images of normal brain MRI and show that our model outperforms baseline models in both quantitative and qualitative measurements. We also train the model to synthesize brain disorder MRI data to demonstrate the wide applicability of our model. Our results suggest that the proposed model can successfully generate various types and modalities of 3D whole brain volumes from a small set of training data.
The recent success of brain-inspired deep neural networks (DNNs) in solving complex, high-level visual tasks has led to rising expectations for their potential to match the human visual system. However, DNNs exhibit idiosyncrasies that suggest their visual representation and processing might be substantially different from human vision. One limitation of DNNs is that they are vulnerable to adversarial examples, input images on which subtle, carefully designed noises are added to fool a machine classifier. The robustness of the human visual system against adversarial examples is potentially of great importance as it could uncover a key mechanistic feature that machine vision is yet to incorporate. In this study, we compare the visual representations of white-and black-box adversarial examples in DNNs and humans by leveraging functional magnetic resonance imaging (fMRI). We find a small but significant difference in representation patterns for different (i.e. white-versus blackbox) types of adversarial examples for both humans and DNNs. However, human performance on categorical judgment is not degraded by noise regardless of the type unlike DNN. These results suggest that adversarial examples may be differentially represented in the human visual system, but unable to affect the perceptual experience.
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