Salvileucalin B (2), having an unprecedented rearranged neoclerodane skeleton, was isolated from the aerial parts of Salvia leucantha Cav. (Labiatae) along with salvileucalin A (1). The absolute structures were elucidated by spectroscopic analysis, X-ray crystallographic analysis, and vibrational circular dichroism. Compound 2 represents a novel neoclerodane, characterized by a tricyclo[3.2.1.0 (2,7)]octane substructure incorporating the exocyclic C-20 methylene of 1. This molecule exerted cytotoxic activity against A549 and HT-29 cells with IC50 values of 5.23 and 1.88 microg/mL, respectively.
Terpenes U 0200 Salvileucalin B, a Novel Diterpenoid with an Unprecedented Rearranged Neoclerodane Skeleton from Salvia leucantha Cav. -The cytotoxic title compound (I) is isolated together with salvileucalin A (II). -(AOYAGI, Y.; YAMAZAKI, A.; NAKATSUGAWA, C.; FUKAYA, H.; TAKEYA*, K.; KAWAUCHI, S.; IZUMI, H.; Org. Lett. 10 (2008) 20, 4429-4432; Sch. Pharm., Tokyo Univ. Pharm. Life Sci., Hachioji, Tokyo 192-03, Japan; Eng.) -Lindner 10-181
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.