The manufacture of high-quality cars at comparatively low-cost has gradually become the mainstream. Our study designs a set of integrated time-driven-activity-based costing (TDABC) of performance-oriented systems using the bottleneck-breaking concept of theory of constraints (TOC). We use it to provide timely and relevant information on operation resources and cost management, which is an urgent issue. Through applications of TOC to TDABC, we further integrate cost concepts into the information system of the enterprise to achieve the following objects: First, the company can concentrate its limited resources on the main problem of bottleneck operations to effectively solve the inconsistency between individual departments and overall objects of the company. Second, in business process management, the company leads all operation processes to follow three major performance indicators. Third, the production-planning units are assisted in applying the specifications and definition of product to the manufacturing cost analysis of new product development. Fourth, in the delivery time, the production and management units are assisted in giving priority to the bottleneck operations when facing rush orders. Finally, in process improvement, improving bottleneck operations fast is the key for overall profits of the corporation.
The incidence of limb defects, especially the severe types, was increased after CVS. The spectrum of limb defects with CVS exposure was more severe than the limb defects seen in the general population and showed a specific pattern ranging from hypodactyly, adactyly, and transverse limb reduction, to oromandibular-limb hypogenesis. A correlation between the severity of limb defects and the timing of CVS was suggested.
This study developed a microfluidic platform for replicating and detecting DNA in real time by integrating a laser and a microfluidic device composed of polydimethylsiloxane. The design of the microchannels consisted of a laser-heating area and a detection area. An infrared laser was used as the heating source for DNA replication, and the laser power was adjusted to heat the solutions directly. In addition, strong biotin–avidin binding was used to capture and detect the replicated products. The biotin on one end was bound to avidin and anchored to the surface of the microchannels, whereas the biotin on the other end was bound to the quantum dots (Qdots). The results showed that the fluorescent intensity of the Qdots bound to the replicated products in the detection area increased with the number of thermal cycles created by the laser. When the number of thermal cycles was ≥10, the fluorescent intensity of the Qdots was directly detectable on the surface of the microchannels. The proposed method is more sensitive than detection methods entailing gel electrophoresis.
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