People with oral cavity cancer were more likely to continue smoking after the treatment if they had low social support, depression, greater nicotine dependence and poor social-emotional function. Healthcare professionals should pay more attention to social support, psychological status and nicotine dependence of people who were treated for oral cavity cancer.
Background
Glucose-6-phosphate dehydrogenase deficiency is a rarely recognized predisposing factor for rhabdomyolysis. Rhabdomyolysis with coronavirus disease 2019 has been increasingly seen during the pandemic. We report the uncommon occurrence of coronavirus disease 2019 pneumonia, severe rhabdomyolysis, and acute renal failure in the setting of glucose-6-phosphate dehydrogenase deficiency.
Case presentation
A 19-year-old African American male presented with myalgias, diaphoresis, and dark urine. Testing for severe acute respiratory syndrome coronavirus 2 was positive. He had severe rhabdomyolysis with creatine kinase levels up to 346,695 U/L. He was oliguric and eventually required hemodialysis. Progressive hypoxemia, methemoglobinemia, and hemolytic anemia occurred following one dose of rasburicase for hyperuricemia. Glucose-6-phosphate dehydrogenase deficiency was diagnosed. Full recovery followed a single volume exchange transfusion and simple packed red blood cell transfusions.
Conclusions
Glucose-6-phosphate dehydrogenase deficiency may predispose individuals to rhabdomyolysis due to severe acute respiratory syndrome coronavirus 2, presumably due to altered host responses to viral oxidative stress. Early screening for glucose-6-phosphate dehydrogenase deficiency can be useful for management of patients with rhabdomyolysis.
Three high-sensitivity neutron detectors have been set up for monitoring neutrons from the commissioning of a 150-MeV LINAC: the first one is a bare cylindrical He-3 proportional counter with a high sensitivity of ~54 cps/nv to thermal neutrons, the second one uses the same neutron probe but wrapped with 6.5 cm thick polyethylene as a moderator optimized for neutrons in MeV range, the third one is an extended version of the second detector with a layer of lead embedded in the moderator aiming to increase the sensitivity of high-energy neutrons. Their response functions to both neutrons and high-energy gamma rays were calculated using MCNPX. Absolute neutron and gamma-ray spectra at the location of measurement were estimated by FLUKA simulations with a high-fidelity geometry model. Detector responses obtained by folding the spectra with response functions were analyzed and compared with measurements. This paper presents the design and characteristics of these detectors as well as a data analysis of the measured results taken during a full-power LINAC operation.
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