We examined the inhibitory effects of aqueous ethanol extract from mulberry leaves (ME) on postprandial hyperglycemia in normal Wistar rats. ME dose-dependently sup pressed the postprandial rise of blood glucose in rats, when ME (0.02-0.5g/kg) was given
Mulberry leaf extract was studied toxicologically in male and female SD rats. The extract was administered orally at concentrations of 0̮ (control group), 0.1̮, 0.4̮ and 1̮ in basal diet for 90 days. No remarkable change in test animals of both sexes was observed in terms of body weight gain or at necropsy. Hematology and blood chemistry revealed no abnormalities. Pathological examination revealed no toxic change in any organ observed. These findings indicate that dietary intake of 1̮ mulberry leaf extract for 90 days (884.5 mg/kg/day for males and 995.7 mg/kg/day for females as mean daily intake) causes no toxicological change in rats.
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