PVA and gelatin mixed in various volume ratios (100:0, 90:20, 80:20, 70:30, 60:40, 50:50, to 0:100). The effects of the volume ratio on the spinnability of PVA/gelatin solutions were evaluated. The effect on the electrospun nanofiber of PVA/gelatin was examined by IR spectroscopy. Experimental results have demonstrated that solutions of PVA/gelatin in a volume ratio of 80/20 had good spinnability. As the electric field increased, the numbers of beads and droplet decreased. IR spectra demonstrated strong intermolecular hydrogen bonds between the molecules of gelatin and PVA. In this investigation, the best electric field for electrospinning was 0.68 kV/cm. The critical electric field for electrospinning is 0.5 kV/cm.
Sodium alginate (SA) is a polyanionic copolymer consist of mannuronic(M) and guluronic(G) sugar residues, it has been comment used in biomedical applications. In this research, polylactic acid (PLA) and Tencel fiber were fabricated into PLA/Tencel composite nonwoven fabric. Then the gel aqueous Ca-SA was combined with PLA/Tencel composite nonwoven fabric by three-dimensional (3D) coating method to form porosity coating layer. Then LMWCS was sprayed on the whole surface to form antibacterial layer. The physical properties of novel wound dressing were evaluated such as tensile strength, tear strength, water absorption rate, stiffness and SEM. In SEM observation result indicated, the coating layer performs highly porosity structure. Between coating layer and PLA/Tencel composite nonwoven fabric was combined by physical bonding. In this way, PLA/Tencel composite nonwoven fabric can remain some part of air permeability and also enhance the strength of dressing.
Electrospinning has been used in a wide variety of applications, such as tissue engineering, filtration and biomaterial scaffolds for vascular grafts or wound dressings. Recently, wound dressings have become more important in human life. They must have the superior biocompatibility, water absorption, water vapor permeation and antibacterial ability. Chitosan has been employed in clinical applications and exhibits excellent biocompatibility, biodegradation and bacteriostasis. In this investigation OR study, experiments were performed on a series of poly (vinyl alcohol) (PVA)/Chitosan (CS) fiber membranes at various blend ratios and electric fields to evaluate their spinnability. The morphology, diameter and structure of electrospun nanofibers were examined by scanning electron microscopy (SEM). When PVA/Chitosan=80:20 and electric field=0.67 kV/cm, the spinnability of electrospun membrane was good. IR spectra demonstrated strong intermolecular hydrogen bonds between the molecules of Chitosan and PVA. Furthermore, cell cultures demonstrate that both PAV and chitosan have good biocompatibility and are non-toxic.
Chitosan and sodium alginate are two prominent biomaterials because they have some unique properties such as good biocompatible and biodegradable. In this study, sodium alginate was as swelling and moisture retention layer; Chitosan was antibacterial layer.Polylactic acid (PLA) blended in different weight ratios with low melting point polylactic acid (LMPLA) to fabricate nonwoven fabric which reinforced by needle punching and hot pressing. Afterward, chitosan/ sodium alginate compound solution were treated by UV light in order to form cross-linking. Then chitosan/ sodium alginate compound solution coated on the PLA nonwoven fabric to make PLA composite dressings. The mechanical properties of chitosan/ sodium alginate membrane and dressing were measured. The optimum parameters of chitosan/sodium alginate composite membrane was treated by UV light for five minutes and the volume ratio of chitosan (3 wt %) and sodium alginate (1 wt %) solution was 8:2. After we coated chitosan/sodium alginate solution on PLA nonwoven fabric, the Tensile strength, and tear strength were upgraded by 80 % and 98 %; its air permeability and flexibility length, however, dropped by 18 % and 60 %, respectively.
Electrospinning is common used in manufacturing ultrafine fibers from a polymer solution. With a high specific surface area, high porosity and good biocompatibility, the elecrospun membranes have extensive applications as biomaterials such as tissue scaffolds and for drug delivery. Silk fibroins (SF), gelatin (G) both have good biocompatibility and are non-toxic. And in previous literature, gelatin nanofiber can be successfully prepared by electrospinning, which was dissolved in formic acid. Tencel, which is extracted from wood pulp, is biodegradable, has a smooth fiber structure, can protect wounds and is irritation-free. Consequently, SF, G and Tencel are widely used in biomedical applications, such as for wound dressings and scaffolds for tissue engineering and so on. In this study, we discussed the applications of different shapes of electrospun membrane such as film, web. After that, the electrospun membrane was combined with Tencel nonwoven to fabricate composite nonwoven. Electrospinning of SF/ G was performed using formic acid as the spinning solvent. Parameters, such as electrical field (15~11 kV), spinning distance (15~7 cm), and volume ratio of SF and G, were analyzed to investigate their effects on electrospinnability and morphology of nanofiber membranes. The morphology of electrospun SF/ G nanofibers was investigated by scanning electron microscopy (SEM). Analytical demonstrate that the optimal electrospinning condition was fibers with an average diameter of 200–300 nm.
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