Two clinical cases of chronic obstructive pulmonary disease (COPD) stage II patients are reported here. One case refers to a patient with hypoxemia associated to severe air flow limitation, chronic bronchitis and frequent exacerbation events. A significant improvement of patient’s conditions was observed after pharmacological treatment with roflumilast. The second case refers to a patient who refused to adhere to prescribed therapy but adhered to roflumilast therapy, eventually achieving a good response. Both cases highlight roflumilast’s efficacy in improving health conditions of COPD patients.
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