A new class of precursors for water-soluble unsaturated carbenes was synthesized by reaction of [Cp*RuCl(PMe 3 ) 2 ] with a terminal alkyne and a propargyl alcohol, each bearing a polyhydroxylated lateral chain derived from D-xylose. In the reaction with the terminal glycoynitol, the presence of a pair of noninterconverting π-alkyne intermediates of [Cp*Ru-(PMe 3 ) 2 ] + species was observed for the first time and the kinetics of isomerization to the same vinylidene species measured by NMR experiments.
Ring opening of amino epoxides derived from naturally occurring amino acids with lithium diphenylphosphido borane is reported as an efficient approach to a new family of enantiomerically enriched multifunctional phosphines.
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