In this letter, a new algorithm for millimeter wave multiple-input-multiple-output hybrid (mixed RF and baseband) transceiver design is proposed. The proposed algorithm iteratively updates the phases of the phase-shifters in the RF precoder (or RF combiner) to minimize the weighted sum of squared residuals between the optimal full-baseband design and the hybrid design, and is guaranteed to converge to at least a local optimal solution. Simulation results show that the proposed iterative design can achieve almost the same performance as the optimal full-baseband design, in spite of using a much smaller number of RF chains.

Ceramide is a member of the sphingolipid family of bioactive molecules demonstrated to have profound, diverse biological activities. Ceramide is a potential chemotherapeutic agent via the induction of apoptosis. Exposure to ceramide activates extracellular-signal-regulated kinases (ERK)1/2- and p38 kinase-dependent apoptosis in human ovarian cancer OVCAR-3 cells, concomitant with an increase in the expression of COX-2 and p53 phosphorylation. Blockade of cyclooxygenase-2 (COX-2) activity by siRNA or NS398 correspondingly inhibited ceramide-induced p53 Ser-15 phosphorylation and apoptosis; thus COX-2 appears at the apex of the p38 kinase-mediated signaling cascade induced by ceramide. Induction of apoptosis by ceramide or resveratrol was inhibited by the endocytosis inhibitor, cytochalasin D (CytD); however, cells exposed to resveratrol showed greater sensitivity than ceramide-treated cells. Ceramide-treated cells underwent a dose-dependent reduction in trans-membrane potential. Although both ceramide and resveratrol induced the expressions of caspase-3 and -7, the effect of inducible COX-2 was different in caspase-7 expression induced by ceramide compared to resveratrol. In summary, resveratrol and ceramide converge on an endocytosis-requiring, ERK1/2-dependent signal transduction pathway and induction of COX-expression as an essential molecular antecedent for subsequent p53-dependent apoptosis. In addition, expressions of caspase-3 and -7 are observed. However, a p38 kinase-dependent signal transduction pathway and change in mitochondrial potential are also involved in ceramide-induced apoptosis.

Sensor network technology can revolutionize the study of animal ecology by providing a means of non-intrusive, simultaneous monitoring of interaction among multiple animals. In this paper, we investigate design, analysis, and testing of acoustic arrays for localizing acorn woodpeckers using their vocalizations. 1, 2 Each acoustic array consists of four microphones arranged in a square. All four audio channels within the same acoustic array are finely synchronized within a few micro seconds. We apply the approximate maximum likelihood (AML) method 3 to synchronized audio channels of each acoustic array for estimating the direction-of-arrival (DOA) of woodpecker vocalizations. The woodpecker location is estimated by applying least square (LS) methods to DOA bearing crossings of multiple acoustic arrays. We have revealed the critical relation between microphone spacing of acoustic arrays and robustness of beamforming of woodpecker vocalizations. Woodpecker localization experiments using robust array element spacing in different types of environments are conducted and compared. Practical issues about calibration of acoustic array orientation are also discussed.

We investigate the maximum likelihood (ML) direction-of-arrival (DOA) estimation of multiple wideband sources in the presence of unknown nonuniform sensor noise. New closed-form expression for the direction estimation Cramér-Rao-Bound (CRB) has been derived. The performance of the conventional wideband uniform ML estimator under nonuniform noise has been studied. In order to mitigate the performance degradation caused by the nonuniformity of the noise, a new deterministic wideband nonuniform ML DOA estimator is derived and two associated processing algorithms are proposed. The first algorithm is based on an iterative procedure which stepwise concentrates the log-likelihood function with respect to the DOAs and the noise nuisance parameters, while the second is a noniterative algorithm that maximizes the derived approximately concentrated loglikelihood function. The performance of the proposed algorithms is tested through extensive computer simulations. Simulation results show the stepwise-concentrated ML algorithm (SC-ML) requires only a few iterations to converge and both the SC-ML and the approximately-concentrated ML algorithm (AC-ML) attain a solution close to the derived CRB at high signal-to-noise ratio.

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Evodiamine (EVO), an alkaloidal compound isolated from Evodia rutaecarpa (Juss.), has been reported to affect many physiological functions. Topoisomerase inhibitors have been developed in a variety of clinical applications. In the present study, we report the topoisomerase I (TopI) inhibitory activity of EVO, which may have properties that lead to improved therapeutic benefits. EVO is able to inhibit supercoiled plasmid DNA relaxation catalyzed by TopI. Upon treatment 0~10 μM EVO TopI was depleted in MCF-7 breast cancer cells in a concentration-dependent and time-dependent manner in 0~120 min. A K-SDS precipitation assay was performed to measure the extent of Top I-trapped chromosomal DNA. The ability of EVO to cause the formation of a TopI-DNA complex increased in a concentration-dependent manner, in that the DNA trapped increased by 24.2% in cells treated with 30 μM. The results suggest that EVO inhibits TopI by stabilizing the enzyme and DNA covalent complex.

This article presents a new MSE-based transceiver design for the MIMO interference channel (IC). The proposed design monotonically decreases the maximum per-stream MSE of all users by alternatively optimizing between a minimum MSE solution for the equalizers and a second-order-cone-programming (SOCP) solution for the precoders. As the system's error rate performance at high signal-to-noise ratio (SNR) is dominated by the spatial stream with the largest MSE, minimizing the maximum per-stream MSE not only improves the overall system performance but also ensures the fairness in error rate among users. The performance advantage of the proposed algorithm is verified by the numerical simulations.

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