The aim of this study was to investigate changes in task-related brain oscillations and corticocortical connections in patients with mild cognitive impairment (MCI) and those with normal aging using cross-mutual information (CMI) analysis. We hypothesized that task-related brain oscillations and corticocortical connections were affected by age- and disease-related changes, which could be reflected in the CMI analysis. Electroencephalogram (EEG) recordings were measured in 16 MCI patients, 15 healthy age-matched controls, and 16 healthy younger individuals. The frequencies and interhemispheric CMI data were estimated in all groups. The specific EEG rhythms measured were delta (δ), theta (θ), alpha (α), beta (β), and gamma (γ) bands. Significant differences in δ, θ, α, and β bands were observed between the younger and elderly groups. However, only the θ band was significantly different between the elderly and MCI groups. Moreover, this study used EEG recordings to investigate age- and disease-related changes in the corticocortical connections of the brain. This study proves that the θ-band frequency of the connection between the parietal and occipital lobes for the age- and disease-related changes can be depicted using the CMI analysis.
During the past few years, many researchers have demonstrated the importance of the agerelated changes in spontaneous electroencephalography. However, very little research on of the event-related responses of oscillations connections has been used to examine the changes during normal aging. The aim of the present study was to investigate age-related changes of task-related brain oscillations, which include spectral power and omega-complexity. We hypothesized that the power and omega-complexity of the brain are affected by age-related changes, which could be observed in this study. The samples included young and healthy elderly groups. Compared to young participants, elderly participants were found to have increased power in anterior area and decreased power in posterior area, and have shown a decreased power in the alpha-1 (7 -10 Hz) and alpha-2 (10 -13 Hz) bands and an increased power in the delta (1 -4 Hz) band. Elderly participants were found to have increased omega-complexity in the anterior and posterior brain areas, and have shown an increased omega-complexity in the alpha-2, beta-1 (13 -18 Hz), and beta-2 (18 -30 Hz) bands. The findings in this study suggest that power and omega-complexity changes in task-specific neural activity may potentially be used to assess age-related decline in the brain.
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