Unlike the major HBV surface antigen, LHBS is mostly expressed in the tumorous regions of HBV-induced HCC, indicating that it plays a unique role in tumor progression; the relative level of pre-S mutant in serum is, independently of tumor stage, an important high-risk marker for HCC recurrence after primary hepatic resection. (Hepatology 2018).
The Drosophila transcription factor (TF) Zfh1 has distinct roles compared to the cell lineage‐determining TFs in almost all mesoderm‐derived tissues. Here, we link Zfh1 to the well‐characterized mesodermal transcriptional network. We identify five enhancers integrating upstream regulatory inputs from mesodermal TFs and directing zfh1 expression in mesoderm. Most downstream Zfh1‐target genes are co‐bound by mesodermal TFs, suggesting that Zfh1 and mesodermal TFs act on the same sets of co‐regulated genes during the development of certain mesodermal tissues. Furthermore, we demonstrate that Zfh1 is critical for the expression of a hemocyte marker gene peroxidasin and helps restrict the activity of a hemocyte‐specific enhancer of serpent to hemocyte‐deriving head mesoderm, suggesting a potential role of Zfh1 in hemocyte development.
This letter presents a second-order incremental ADC (IADC) operated in three steps, which extends the performance of a second-order IADC close to that of a fourth-order IADC with only two amplifiers. It performs a second-order noise-shaping quantization in the first step operation. Reusing the same hardware, the circuit is reconfigured to perform fine quantization as a first-order IADC in the second and third step. Within a conversion time of 60 clock periods (oversampling ratio OSR = 60), 35 dB signal-to-quantizationnoise ratio is boosted. The proposed topology is very suitable for low-bandwidth highresolution data conversion.
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