BackgroundSexually explicit media exposure during early adolescence has been found to be associated with risky sexual behavior. However, previous study suffered from methodological issue, such as selection bias. Furthermore, little is known about the effect of multi-modality sexually explicit media exposure on risky sexual behavior, and how this relationship can be applied to non-western societies.

No abstract

Using data from the TYP (Taiwan Youth Project) panel survey, we examine factors associated with early marriages in Taiwan and the subsequent risks for negative outcomes in family life and career trajectories. About 7% of Taiwanese people marry early, that is, before the age of 28 years. Among those who marry early, more than 60% report the birth of a child within the first 8 months of marriage (i.e., they form postconception “shotgun” marriages). Compared with the never married respondents, individuals in both preconception and postconception early marriages are likely to come from families of low socioeconomic status. Nonworking young adults and those experiencing parental divorce or parental death during adolescence are at higher risk of entering postconception marriages than those remaining single. Particularly for nonemployed young people and those from lower socioeconomic status background, early marriage means taking on adult responsibilities in a disadvantaged state.

No abstract

Breast cancer is a global issue regarding women’s health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported. This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study. A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria. These criteria included the patient’s preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade. All data were collected according to an institutional review board approved protocol. The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences. Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.