Predictability estimated through cross-validation approach showed moderate to high level; hence, genomic selection approach holds great potential for biofortification breeding to enhance grain zinc and iron concentrations in wheat. Wheat (Triticum aestivum L.) is a major staple crop, providing 20 % of dietary energy and protein consumption worldwide. It is an important source of mineral micronutrients such as zinc (Zn) and iron (Fe) for resource poor consumers. Genomic selection (GS) approaches have great potential to accelerate development of Fe- and Zn-enriched wheat. Here, we present the results of large-scale genomic and phenotypic data from the HarvestPlus Association Mapping (HPAM) panel consisting of 330 diverse wheat lines to perform genomic predictions for grain Zn (GZnC) and Fe (GFeC) concentrations, thousand-kernel weight (TKW) and days to maturity (DTM) in wheat. The HPAM lines were phenotyped in three different locations in India and Mexico in two successive crop seasons (2011-12 and 2012-13) for GZnC, GFeC, TKW and DTM. The genomic prediction models revealed that the estimated prediction abilities ranged from 0.331 to 0.694 for Zn and from 0.324 to 0.734 for Fe according to different environments, whereas prediction abilities for TKW and DTM were as high as 0.76 and 0.64, respectively, suggesting that GS holds great potential in biofortification breeding to enhance grain Zn and Fe concentrations in bread wheat germplasm.

Despite the existence of several policies and programs, anemia among pregnant and lactating women continues to be a serious concern for public health policy in India. The main objective of this study is to examine the prevalence and determinants of anemia among pregnant and lactating versus nonpregnant nonlactating (NP-NL) women for priority setting in health policies of the country. Data from the National Family Health Survey (NFHS3) conducted in 2005-2006 has been used for the analyses of this study. The results revealed that the prevalence of anemia was higher among lactating women (63%), followed by pregnant women (59%) than NP-NL women (53%). Younger lactating (71%) and older pregnant women (67%) had a higher burden of anemia. Along with socioeconomic factors, demographic indicators such as children ever born and program factors like nutrition advice and supplementary nutrition during anti natal care and postnatal care emerged as significant predictors in the case of anemia among both pregnant and lactating women, while socioeconomic indicators emerged as critical factors in the case of anemia among NP-NL women. Hence, targeting demographic and program factors, along with key socioeconomic and demographic factors in public health policy, is critical in reducing anemia among lactating and pregnant women, while targeting significant socioeconomic factors is the key for reducing anemia among NP-NL women.

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The main objective of the HarvestPlus led wheat biofortification breeding program at the International Maize and Wheat Improvement Center (CIMMYT) and its national program partners in South Asia is to develop and disseminate competitive wheat varieties with high grain zinc (Zn) and other essential agronomic features. The emphasis of this program is to introduce novel sources of genetic diversity from wild species and landraces, into the adapted wheat background. This variation is being exploited through limited backcross approach with shuttle breeding at two contrasting locations in Mexico, which resulted in widely adapted, durable rust and foliar disease resistant, high Zn wheat varieties. The new wheat varieties developed by CIMMYT in HarvestPlus project are 20-40% superior in grain Zn concentration and are agronomically at par or superior to the popular wheat cultivars of South Asia. The biofortification breeding program of CIMMYT utilizes new wheat varieties from the core-breeding program as background parents that are higher yielding, resistant to rusts, heat tolerant, wateruse efficient and 5-10% higher yielding than main varieties grown at present. The biofortified high Zn wheat varieties with 20 to 40% (8-12 mg/kg) Zn superiority and grain yield potential at par or superior to the popular wheat varieties are being adopted by small-holder farmers in South Asia. Through Public-private partnerships (PPP) more than 50,000 farmers and 250,000 household members expected to benefit from the Zn-biofortified wheat varieties in South Asia by the 2015-2016 wheat seasons.

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