Implication of high risk-human Papillomavirus in the process of cervical carcinogenesis is well documented. However, carcinogenesis in the cervix is recognized as multifactorial and other unknown etiological factors are also presumed to contribute to development of cancer. The present communication was aimed to investigate the role of risk factors such as age, parity, cervical lesions, and gynecological symptoms in the progression of the intra-epithelial cervical neoplasia. The study followed 571 cytologically diagnosed cases of high-grade squamous intraepithelial lesions (HSIL) during 35 yr of cytological screening, which is in progress at Gynae OPD of Queen Mary's Hospital of the University since April 1971 and until June 2005, a total of 33,658 cervical smears have been cytologically evaluated. Analysis of different risk factors in 571 HSIL cases revealed high parity coupled with increasing age to play a significant role in the progression of SIL. Further aggravated cervical lesions such as suspicious and unhealthy cervix and persistent vaginal discharge were found to be contributing factor in the progression of SIL. All these factors were predominantly seen in 35 cases of severe dysplasia that have shown progression from moderate dysplasia. The study indicates that women of high parity, especially with high age, are more prone to progression of SIL and hence this group needs mandatory cytological evaluation. Further adequate treatment of mild cervical lesions and persistent vaginal discharge is necessary to avoid the aggravation of the lesion/symptom and subsequent progression of dysplasia.
The level of expression of LIMK1 in cervical cancer patients was found to be significantly higher (P < 0.01) than both the controls and dysplasia. The expression of Aurora B and PLK1 in cervical cancer patients was also found to be significantly higher ( P < 0.05) than controls but it did not differ with dysplasia. However, the expression of Cyclin B1 was similar among cervical cancer patients, dysplasia and controls ( P> 0.05). The expression of all the above proteins showed significant ( P < 0.01) and inverse relation with the survival of cancer patients. Among the selected candidate proteins, it was LIMK1 that showed the most positive correlation with the aggressiveness of the disease and negative correlation (r= -0.64; P < 0.01) with the survival of patients.
Spiders are one of the most fascinating and diverse invertebrates and also potential bio-control agents in agro-ecosystems. Field surveys were carried out at Sundernagar, Jogindernagar, Nurpur and Palampur areas of Himachal Pradesh by two methods namely visual count and sweep net to assess seasonal abundance and diversity of spider, in the rice ecosystems during kharif, 2015 and 2016. It was found that the population trend was well represented by visual count method as compared to sweep net method. Maximum numbers of spiders were recorded from Palampur area followed by Sundernagar, Jogindernagar and Nurpur. Eleven families viz., Oxyopidae, Tetragnathidae, Salticidae, Lycosidae, Pisauridae, Araneidae, Theridiidae, Clubionidae, Sparassidae, Thomisidae and Pholcidae were recorded from the fields with majority belonging to Araneidae and Tetragnathidae. The pre-dominant spider genus from all the locations were Tetragnatha and Neoscona while Araneus pseudosturmii and Runcinia ghorpadei Tikader were confined only to Nurpur and Sundernagar, respectively. A. pseudosturmii and Micropholcus fauroti Simon seem to be the first records from India while R. ghorpadei to be the hitherto unknown male morph.
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