In continuation of our work on the local Rutaceae family, we have investigated the constituents of the bark of Glycosmis rupestris Ridely collected from Langkawi Island and used medicinally, especially the roots, for the treatment of fever, swollen spleen, and as a stimulant to digestion (1, 2). A voucher specimen has been deposited at the herbarium, Department of Botany, Universiti Kebangsaan Malaysia. Previous studies of this genus have revealed the presence of various compounds such as alkaloids, coumarins, and sulphur-containing amides from plant materials collected in Sri Lanka, India, Thailand, and also Malaysia (3-5). In this work we report the isolation and identification of a new carbazole alkaloid 7-methoxyglycomaurin (1) and the known glycomaurin and deN -methylacronycine from C. rupestris Ridely.
The antifungal activity of Glycosmis calcicola B.C. Stone and G. rupestris extracts was evaluated using poison food and spore germination techniques. The CHCl 3 extract of G. calcicola has been shown to be most effective in inhibiting mycelial growth, sporulation, and spore germination on three fungal pathogens of chili. The antifungal compounds were identified as flindersine and desmethoxyanthophylline and their structures were determined by spectroscopic methods and comparison with reported data.
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