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. A mixture of 0.110 g (0.51 mmol) of 9a and 0.050 g (0.95 mmol) of sodium methoxide in 7 ml of methanol was stirred at 25°. After 22 hr, tic showed no more starting material. The mixture was evaporated to 1 ml of liquid and placed on a silica gel preparative tic plate. Elution with 10:85:5 chloroform-Skellysolve B-ethanol gave a band at Ri 0.60 which yielded 30 mg (28%) of 12 as a light yellow oil: ir (neat) 1633 cm""1 (C=N); nmr (CC14) 2.7 (s, 5, aromatic),

Contributed by Cheves Walling, August 5, 1992 ABSTRACT Recent studies on the initial stages in oxidation of low density lipoprotein (LDL) have revealed certain previously unrecognized similarities to emulsion polymerization and some quite unexpected features including the following: (i) ascorbate is an extremely effective antioxidant for LDL containing a-tocopherol (a-TOH); (i) in the presence of a-TOH and in the absence of both ascorbate and ubiquinol 10 (QloH2), oxidation of LDL occurs via a free radical chain; (ii)

The optimal conditions for determining the spin-lattice relaxation times using Fourier transform techniques are discussed and the method which has been applied to polarized species produced by chemically induced dynamic nuclear polarization (CIDNP) has been developed. A number of Ti measurements on the polarized products of benzoyl peroxide decomposition have been made from which carbon-13 CIDNP enhancement factors are determined.

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