We here report the unusual occurrence of bullous pemphigoid mimicking prurigo nodularis in a 59-year-old woman. Direct immunofluorescence studies of a nodular lesion revealed linear deposition of IgG and C3 at the epidermal basement membrane zone (EBMZ). Indirect immunofluorescence studies of serum revealed IgG pemphigoid antibasement membrane zone antibodies in 1:1,280 titer. This entity can be distinguished from other bullous pemphigoid variants.
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