BackgroundBilateral superficial cervical plexus block (BSCPB) provides good postoperative analgesia, but its effect on anesthetic consumption is unknown. This study evaluated the effects of BSCPB on sevoflurane consumption during thyroid surgery.MethodsFifty patients were randomly allocated into groups A and B of 25 each in this prospective double-blind study. Group A received BSCPB with 20 ml 0.25% bupivacaine, whereas group B received 20 ml saline immediately before entropy-guided general anesthesia. Intraoperative hemodynamic parameters, end-tidal sevoflurane concentration, minimum alveolar concentration, and sevoflurane consumption were recorded. Postoperative pain was assessed using a visual analog scale, and the time of the first request for analgesia was noted. All side effects were recorded.ResultsDemographics were comparable. Mean sevoflurane consumption [for 30 min: group A = 7.2 (1.1) ml, group B = 8.8 (2.0) ml, P = 0.001; for 60 min: group A = 13.5 (1.7) ml, group B = 16.5 (3.9) ml, P = 0.002] and mean end-tidal sevoflurane concentration [for 30 min: group A = 1.2% (0.2%), group B = 1.4% (0.2%), P = 0.008; for 60 min: group A = 1.2% (0.1%), group B = 1.4% (0.2%), P = 0.010] were significantly lower in group A. Patients in group A had a longer duration of analgesia [361.6 (79.5) min vs. 151.0 (60.2) min, P < 0.001] compared to those in group B.ConclusionsPreinduction BSCPB during thyroid surgery significantly reduced sevoflurane consumption and increased the duration of postoperative analgesia.

The success of vector management programs relies on knowledge of the biology and genetic make-up of mosquitoes so that they can be interlaced with modern tools for developing suitable intervention strategies. There are many reports available for rearing varied species of mosquito vectors. However, there are limited studies addressing the development of isofemale lines among mosquitoes to homogenize the population to obtain both high-quality genome assemblies and enrichment of phenotype. Anopheles stephensi, an urban malaria vector, is one of the major invasive vectors of malaria distributed throughout the Indian subcontinent, Middle East, and has recently been expanding its range in Africa. With the existence of three biological forms, distinctly identifiable based on the number of ridges on eggs with varying vectorial competence, An. stephensi is a perfect species for developing a method for the successful establishment of isofemale lines, which can be tested for retention of the expected vectorial competence for the various forms. We describe the key steps in the establishment and validation of isofemale lines, which include monitoring the transgenerational fitness traits, morphometrics of eggs, and adult wing size during every generation. After the initial inbreeding depression, as proof of the tedious selection process, no significant morphometric differences were observed in the wings and egg size between the parental and their respective isofemale lines. We observed a significant change in the vectorial competence between the respective isofemale and parental lines enriching expected differential susceptibility towards malaria parasites by the type and intermediate forms. Interestingly, IndCh and IndInt strains showed variations in resistance to different insecticides belonging to all the four major classes. These variant lines have been characterized for their levels of homozygosity both at the phenotype and genotype levels and can be used as a standard reference or as a biological resource for other studies related to urban malaria research.

Background: Stress and anxiety being the major contributors of morbidity, leads to many chronic diseases and is known to invariably decrease the quality of life and even life span. Autonomic Nervous System (ANS), a part of the peripheral nervous system that controls the visceral system, functioning largely under the level of consciousness, capable of being influenced by the psychological factors and influences the physiological processes happening in the body. Non-pharmacological therapies play a major role to relieve stress and anxiety of which yoga takes first place compared to pharmacological treatment. Present study adopts a systematic approach in comparing the effects of practicing yoga for one year with novices on autonomic and respiratory variables. Methods: We recruited sixty subjects from the Sri Dharmasthala Manjunatheshwara College of Naturopathy & Yogic Sciences, Ujire and their mean age group is 18.8 ± 2.3 fulfilling the selection criteria, after they gave written consent to participate. They were divided into 2 groups based on their experience of practicing yoga. Each group consisted of 30 subjects. Group 1 includes participants with no experience in yoga (Novices group) and Group 2 (Yoga group) includes individuals with one year experience of practicing yoga. Each group consists of 17 males and 13 females respectively. The study was approved by the ethical review committee. Informed written consent was obtained from all subjects. All students were subjected to Onetime Assessment for autonomic variables and respiration at base line and during deep breathing. Results: In our study we observed that there was a significant decrease in heart rate (P = 0.004 ***) following intervention in yoga group compared to novice group. There was a significant difference in Respiration rate (P = 0.003 ***) and Mean RR (P = 0.002 ***) which indicate increase parasympathetic activity in yoga group compared to novice group. There is also a significant difference in time domain parameter PNN50 (P = 0.030 *) which is an indicator of parasympathetic activity. There was no significant difference in other time domain and frequency domain parameter. Conclusion: Practicing yoga regularly for one year can reduce the physiological arousal and develops the ability to adapt to a demanding situation.

Abstract:Testing different materials for their fatigue behaviour has been a major requirement before consider the material for use in any environment with continuous fluctuating load. There has been major evolution in the design of fatigue testing machines for over a century now. But the concept that was lacking in the testing industry was that of a fatigue testing machine that can simultaneously test the fatigue strength of two specimen. In this paper, the attempt to bring this concept to life has been explained. The design of this fatigue testing machine is different from other fatigue testing machines because it can hold two specimens at any given time.

Introduction:The following study was conducted to examine the short term clinical and radiological results particularly early complications and healing rate of distal tibia fracture treated by MIPPO using LCP. Methodology: The study was conducted in patients treated for distal tibia fracture (type A, B & C -AO classification) at Adichunchanagiri Institute of Medical Science, BG Nagar from the month of Nov 2013 to Nov 2015. Twenty distal tibia fracture patients were taken into the study, all were fixed with LCP by mippo, some with Bone grafting where the distal tibia fractures were associated with bone loss and communition. Patients' age ranged from 27 to 68 years with a mean of 50. Results: The sample consisted of twenty patients with 11 males and 09 were female. The patients' ages ranged from 27-68 years with a mean age of 50 years. The causes of fractures were motorvehicle accident in 13 patients and fall in 07 patients. There were no sports or industrial accidents. 12 fractures involved the right side and 08 involved the left. The average length of hospitalisation was 15 days with a range of 10 to 20 days. The average number of days from injury to surgery was 5 days with a range of 2 to 10 days. The operative time ranged from 45 minutes to 120 minutes. Patients were followed up from 01 to 24 months. Functional outcome was rated as per The modified ankle score of Olerud and Molander, we got excellent results in 10 cases, good in 07, fair in 02 and poor in one patient. Conclusion:The LCP is a good implant to use for fractures of the distal tibia by mippo method. However, accurate positioning and fixation are required to produce satisfactory results. We recommend use of this implant in Type A, B and C, osteoporotic fractures. Our early results were encouraging but long term studies are needed to prove definitively acceptable outcomes so that the technique can become part of the armamentarium of the orthopaedic trauma surgeon.