Synthesis
of optically active gem-difluorinated organic molecules attracts a great deal of
interest due to their unique properties in pharmaceutical and agrochemical
areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic
esters were prepared in high yields (83–99%) with moderate
to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed
asymmetric hydrogenation.
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