The purpose of this study is to develop a prosthetic ankle joint intelligently controlled by specially designed linear MR (Magneto-Rheological) brake. MR fluid changes its rheology depending on the intension of an applied magnetic field. The brake using MR fluid (we call it MR brake) has a simple structure and can control its braking force with a low voltage. Prosthesis users often tumble because they don't have dorsiflexor , so that we propose putting MR brake taking the place of dorsiflexion. We hope that prosthesis users can walk more naturally and smoothly by use of developed intelligent prosthetic ankle joint with MR brake. We developed a prototype of it and evaluated it with walking experiments before. But there were some problems with the prototype in terms of hardware and experimental environments. Therefore we have developed a 2nd prototype of the intelligent prosthetic ankle joint with the MR brake, which was improved considering previous problems, and then we have carried out the walking experimental evaluation of it.
The first electrophilic asymmetric selenocyanation has been achieved in the presence of Ni(OTf) 2 and (R,R)-DBFOX/Ph using N-selenocyanatosaccharin as the new selenocyanation reagent. Thus, a series of α-selenocyanato-βketo esters were synthesized with high yields (up to 99%) and good ee values (up to 92% ee). The readily preparation of the reagent and high enantioselectivity make this methodology much practical for the synthesis of chiral selenocyanates.
N-Thiocyanato-dibenzenesulfonimide: a new electrophilic thiocyanating reagent was readily prepared and exhibited enhanced reactivity with a wide scope of substrates.
Impaired myocardial contractile function, one of the well-documented features of sepsis, contributes greatly to the high rate of mortality. Quercetin is widely accepted as a potential antioxidant and free radical scavenger. Epidemiologic studies have suggested that an increase in the intake of dietary Quercetin can reduce the risk of cardiac disease. However, presently there is no report yet on the influence of Quercetin on LPS-induced myocardial dysfunction in vivo. Cardiovascular protective effects of Quercetin on LPS-induced sepsis in mice were measured after intragastric administration, using normal saline as a positive control. Quercetin pretreatment significantly alleviated LPS-induced cardiac abnormalities in mice. The histopathologic findings in the present study justify the findings reported from the biochemical analyses. Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines at different levels, such as TNF-α and IL-1β, and inhibits the activation of I-κB phosphorylation, whereas the total content was not affected. Apoptotic pathways are related to Quercetin protection in the development of myocardial dysfunction. In conclusion, our findings demonstrate the adjuvant potentials of Quercetin for clinical sepsis treatment.
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