Abstract.A 34-KD protein encoded by the SEI-1 gene (p34 ), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show that p34 SEI-1 enhances cancer cell survival and promotes tumorigenesis by downregulating the tumor suppressor PTEN, a negative regulator of the PI3K/AKT signaling pathway, and therefore activating the PI3K/AKT signaling pathway. In this process, p34 SEI-1 positively affects NEDD4-1 gene expression both at the transcriptional and protein levels. Furthermore, the expression levels of p34 SEI-1 and NEDD4-1 were found to be coordinated in tumor tissues obtained from patients with breast cancer. We also show that p34 SEI-1 affects the subcellular localization of PTEN.
TRIP-Br1 oncogenic protein has been shown to have multiple biological functions in cells. In this study, we demonstrate that TRIP-Br1 functions as an oncoprotein by inhibiting autophagy, apoptosis, and necroptosis of cancer cells and eventually helping them to survive under the nutrient/serum starved condition. TRIP-Br1 expression level was significantly increased in conditions with low levels of nutrients. Nutrient depleted conditions were induced by culturing cancer cells until they were overcrowded with high cell density or in media deprived of glucose, amino acids, or serum. Among them, serum starvation significantly enhanced the expression of TRIP-Br1 only in all tested breast cancer cell lines (MCF7, MDA-MB-231, T47D, MDA-MB-435, Hs578D, BT549, and MDA-MB-435) but not in the three normal cell lines (MCF10A, HfCH8, and NIH3T3). As compared with the control cells, the introduction of TRIP-Br1 silencing siRNA into MCF7 and MDA-MB-231 cells accelerated cell death by inducing apoptosis and necroptosis. In this process, TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. Moreover, our data also show that the intracellular increase of TRIP-Br1 protein resulting from serum starvation seems to occur in part through the blockage of PI3K/AKT signaling pathway.
A facile generic template-free strategy is employed to prepare hierarchical hollow hybrid Fe2O3@MIL-101(Fe)/C materials derived from metal-organic frameworks as anode materials for Na-ion batteries. The intrinsic hollow nanostructure can shorten the lengths for both electronic and ionic transport, enlarge the surface areas of electrodes, and improve accommodation of the volume change during Na+ insertion/extraction cycling. Therefore, The stable reversible capacity of Fe2O3@MIL-101(Fe)/C electrode is 710 mAhg−1, and can be retained at 662 mAhg−1 after 200 cycles with the retention of 93.2%. Especially, its overall rate performance data confirm again the importance of the hierarchical hollow structures and multi-elements characteristics toward high capacities in both low and high current rates. This general strategy may shed light on a new avenue for fast synthesis of hierarchic hollow functional materials for energy storage, catalyst, sensor and other new applications.
Hollow magnetic Fe3O4@NH2-MIL-101(Fe) derived from metal-organic frameworks are fabricated through a general facile strategy. The synthetic parameters are regulated to control the shape of the as-prepared samples. The concentration of phosphates decreased sharply from the initial 0.60 to 0.045 mg.L−1 with the exposure time in 50 minutes. The correlation between the most significant parameters such as contact time, adsorbent dose, pH, as well as adsorption capacities was optimized, and the effects of these parameters on the removal efficiency of phosphates were investigated. Surface functionalization of magnetic hollow materials is a well-designed way to bridge the gap between high adsorption activity, excellent separation and recovery of phosphates from the water treatment system. Therefore, it exhibits a remarkable selective removal of phosphates from aqueous solution.
FeS‐based composites are sustainable conversion electrode materials for lithium‐ion batteries, combining features like low cost, environmental friendliness, and high capacities. However, they suffer from fast capacity decay and low electron conductivity. Herein, novel insights into a surprising phenomenon of this material are provided. A FeS/Fe3C/C nanocomposite synthesized by a facile hydrothermal method is compared with pure FeS. When applied as anode materials for lithium‐ion batteries, these two types of materials show different capacity evolution upon cycling. Surprisingly, the composite delivers a continuous increase in capacity instead of the expected capacity fading. This unique behavior is triggered by a catalyzing effect of Fe3C nanoparticles. The Fe3C phase is a beneficial byproduct of the synthesis and was not intentionally obtained. To further understand the effect of interconnected carbon balls on FeS‐based electrodes, complementary analytic techniques are used. Ex situ X‐ray radiation diffraction and ex situ scanning electron microscopy are employed to track phase fraction and morphology structure. In addition, the electrochemical kinetics and resistance are evaluated by cyclic voltammetry and electrochemical impedance spectroscopy. These results reveal that the interconnected carbon balls have a profound influence on the properties of FeS‐based electrodes resulting in an increased electrode conductivity, reduced particle size, and maintenance of the structure integrity.
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