A physical impregnation method is presented in this study, providing a facile approach to encapsulating functional guest molecules (GMs) into robust crystalline supramolecular organic frameworks incorporating cucurbit[10]­uril (Q[10]-SOF). As Q[10]-SOF has high evaporated pyridine affinity under normal atmospheric pressure, pyridine molecules in this method were successfully encapsulated into the nanospace formed by GMs and Q[10]-SOF while retaining their crystal framework, morphology, and high stability. GMs@Q[10]-SOF solid materials were found to respond to pyridine, being suitable to be used as solid sensors. Notably, Q[10]-SOF loading with pyrene exhibited a unique response to pyridine along with dramatic fluorescence quenching; loading with dansyl chloride exhibited a unique response to pyridine along with significant fluorescence enhancement, having a quick response within 60 s. Our findings represent a critical advancement in the design of pyridine detection and adsorption for commercial gas identification and sensing.

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