An amino-hydroxy-functionalized strongly fluorescent hybrid silicon quantum dots (znoSiQDs) were prepared by a green and simple method. Waterborne polyurethane-based hybrid fluorescent silicon Quantum dots (znoSiQDs-WPU) was prepared by a modified acetone method using znoSiQDs as chain extender.The structure and properties were also investigated by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analyzer (TGA), fluorescence spectroscopy (FL), and so on. ZnoSiQDs was successfully connected to the polyurethane backbone by covalent bonding. ZnoSiQDs-WPU can effectively shield UV in the range of 300-400 nm. Compared with WPU, the UV shielding range of znoSiQDs-WPU is significantly larger, attributed to the direct band gap transition Γ ! Γ. The fluorescence intensity of znoSiQDs-WPU was dramatically enhanced compared with that of znoSiQDs. Compared with znoSiQDs, the maximum emission peak of znoSiQDs-WPU is blue shifted at about 18 nm, which was related to the increased polarity of the imidazole chromophore. The luminous life of znoSiQDs-WPU is up to 6.58 ns. The thermal stability of znoSiQDs-WPU is improved by bonding znoSiQDs to the main chains of WPU. Furthermore, it is water as a solvent, especially suitable for safety, green, environment amity of materials.
Purpose: The aim of this study was to explore the correlation between
brain functional network alterations and cerebrospinal fluid (CSF)
pathological biomarkers in Alzheimer’s disease (AD)-spectrum patients.
Method: A total of 39 individuals were recruited, including 23 AD
patients and 16 control subjects. All subjects underwent a battery of
neuropsychological examinations, CSF measurement and multimodal magnetic
resonance imaging scans. Independent component analysis was used to
investigate the differences of functional connectivity(FC)among the
two groups based on the resting-sate functional MRI (fMRI) data. Then
correlation analyses were used to estimate the potential relationship
between functional network alterations and cerebral amyloid and tau
burden. Result: Multiple inter- and intra-network functional connections
were altered in AD patients compared to the Non ADCI group. Alterations
in FC between VN and PCC, as well as the functional connections of SMN
were found to be associated with the dynamic changes of CSF Tau.
Compared the AD group with the non-AD CI group, the aforementioned
altered functional brain connectivity, with the exception of FC in the
PCC and VN, was significantly associated with a decrease in CSF Aβ
Conclusion: This study provides provisional evidence that the brain
functional network alterations was closely associated with CSF
pathological characteristics, and these exploratory results support new
research ideas for the early diagnosis of AD.
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