Softness, adhesion, stretchability, and fast recovery
from large
deformations are essential properties for conductive elastomers that
play an important role in the development of high-performance soft
electronics. However, it remains an ongoing challenge to obtain conductive
elastomers that combine these properties. We have fabricated a super
soft (Young’s modulus 2.3–12 kPa), highly stretchable
(up to 1500% strain), and underwater adhesive silicone conductive
elastomer composite (SF-C-PDMS) by incorporating dimethyl silicone
oil as a lubricating agent in a cross-linked molecular network. The
resultant SF-C-PDMS not only exhibits superior softness but also can
readily recover after a strain of 1000%. The initial resistance only
decreases by 8% after 100000 cycles of tensile fatigue test (100%
strain, 0.5 Hz, 15 mm/s). This multifunctional silicone conductive
elastomer composite is obtained in a one-step preparation at room
temperature using commercially available materials. Moreover, we illustrate
the capabilities of this composite in motion sensing.
Rosiglitazone (Avandia) and Pioglitazone (Actos) belong to the class of thiazolidinedione drugs that act by increasing insulin sensitivity and are widely used for treating diabetic patients with insulin resistance. Thiazolidinediones (TZDs) exhibit anti-inflammatory and antioxidant properties and inhibit endothelial cell inflammation and dysfunction, and then play a role in inhibiting plaque formation and coronary atherosclerosis. But the results of evidence-based medicine suggest that thiazolinedione may increase the risk of myocardial infarction. To explore the dispute in depth, the meta-analysis aimed to evaluate the changes in vascular endothelial and plaque-related indicators following treatment with thiazolidinediones on diabetic patients with coronary atherosclerosis.According to our meta-analysis, Thiazolinediones showed a protective effect on the vascular endothelium and an inhibiting effect on plaque progression in patients with diabetes and coronary atherosclerosis and these effects may not depend on related targets or pathways such as inflammation and lipid regulation. Due to the poor quality of the evidence, more and higher-quality studies are needed to further improve the above conclusions.
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