1 The mechanism of vasorelaxation for phosphodiesterase I11 inhibitors is mediated by increase of cAMP whereas for nitrovasodilators, cGMP. Pretreatment with the combination depressed contraction to a higher extend compared with milrinone alone (P < 0.05) for the K+-induced contraction and to NTG alone ( P < 0.05) in U46619-induced contraction. Treatment with the combination also shifted ECS0 rightward and this shift was significantly more than that caused by treatment with NTG alone (P
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