Background: Some retinoid X receptor (RXR) agonists have potential as cancer drugs. Results: Structures of RXR in complex with two different agonists show similar folds. Dynamics analysis reveals unique ligand-induced dynamics in helices 3, 11, and 12. Conclusion: Two networks of interactions that connect RXR agonists to coactivator binding are defined. Significance: Recognition of common conformational changes and distinguishing dynamics of RXR-selective agonists is necessary for advances in drug design.
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