Using phenyliodine diacetate as an oxidant and nickel
acetate as
a promoter, a wide range of unsymmetric thiosulfonates could be furnished
easily in moderate to excellent yields starting from N-substituted O-thiocarbamates and sodium sulfinates. This protocol features
mild conditions, short reaction times, and high atomic utilization,
which can provide an alternative method for the synthesis of unsymmetric
thiosulfonates. In addition, the reaction could be scaled up on a
gram scale, showing potential application value in industry.
An odourless and efficient protocol for the synthesis of benzyl phenyl sulfides was reported. Starting from environmentally friendly phenyldithiocarbamates and commercially available benzyl halides as starting materials, the target compounds (benzyl phenyl sulfides) could be obtained smoothly and easily by using copper salt as catalyst and Cs2CO3 as base. This method features ligand/additive free, the use of readily available starting materials, inexpensive catalysts, and good substrate suitability, illustrating its potential synthetic value for the convenient preparation of some biologically active molecules.
A highly efficient and convenient method for the waterinvolved synthesis of β-keto dithiocarbamates has been developed. In the presence of minimal water, the desired products were obtained in good to excellent yields by using thiuram disulfide reagents and substituted α-haloacetophe-nones as starting materials. This protocol features high atom economy, mild conditions, good functional tolerance and good to excellent yields, showing potential value for the preparation of some biologically and pharmaceutically active compounds.