Defects of the ventral body wall are prevalent birth anomalies marked by deficiencies in body wall closure, hypoplasia of the abdominal musculature and multiple malformations across a gamut of organs. However, the mechanisms underlying ventral body wall defects remain elusive. Here, we investigated the role of Wnt signaling in ventral body wall development by inactivating Wls or β-catenin in murine abdominal ectoderm. The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt proteins, resulted in dysgenesis of ventral musculature and genito-urinary tract during embryonic development. Molecular analyses revealed that the dermis and myogenic differentiation in the underlying mesenchymal progenitor cells was perturbed by the loss of ectodermal Wls. The activity of the Wnt-Pitx2 axis was impaired in the ventral mesenchyme of the mutant body wall, which partially accounted for the defects in ventral musculature formation. In contrast, epithelial depletion of β-catenin or Wnt5a did not resemble the body wall defects in the ectodermal Wls mutant. These findings indicate that ectodermal Wnt signaling instructs the underlying mesodermal specification and abdominal musculature formation during ventral body wall development, adding evidence to the theory that ectoderm-mesenchyme signaling is a potential unifying mechanism for the origin of ventral body wall defects.
For the problem of sensor faults and actuator faults in aircraft attitude control, this paper proposes a fault tolerant control (FTC) scheme based on extended state observer (ESO) and nonlinear dynamic inversion (NDI). First, two ESOs are designed to estimate sensor faults and actuator faults respectively. Second, the angular rate signal is reconstructed according to the estimation of sensor faults. Third, in angular rate loop, NDI is designed based on reconstruction of angular rate signals and estimation of actuator faults. The FTC scheme proposed in this paper is testified through numerical simulations. The results show that it is feasible and has good fault tolerant ability.
Purpose This paper aims to focus on the sensor fault-tolerant control (FTC) for civil aircraft under exterior disturbance. Design/methodology/approach First, a three-step cubature Kalman filter (TSCKF) is designed to detect and isolate the sensor fault and to reconstruct the sensor signal. Meanwhile, a nonlinear disturbance observer (NDO) is designed for disturbance estimation. The NDO and the TSCKF are combined together and an NDO-TSCKF is proposed to solve the problem of sensor faults and bounded disturbances simultaneously. Furthermore, an FTC scheme is designed based on the nonlinear dynamic inversion (NDI) and the NDO-TSCKF. Findings The method is verified by a Cessna 172 aircraft model under bias gyro fault and constant angular rate disturbance. The proposed NDO-TSCKF has the ability of signal reconstruction and disturbance estimation. The proposed FTC scheme is also able to solve the sensor fault and disturbance simultaneously. Research limitations/implications NDO-TSCKF is the novel algorithm used in sensor signal reconstruction for aircraft. Then, disturbance observer-based FTC can improve the flight control system performances when the system with faults. Practical implications The NDO-TSCKF-based FTC scheme can be used to solve the sensor fault and exterior disturbance in flight control. For example, the bias gyro fault with constant angular rate disturbance of a civil aircraft is studied. Social implications Signal reconstruction for critical sensor faults and disturbance observer-based FTC for civil aircraft are useful in modern civil aircraft design and development. Originality/value This is the research paper studies on the signal reconstruction and FTC scheme for civil aircraft. The proposed NDO-TSCKF is better than the current reconstruction filter because the failed sensor signal can be reconstructed under disturbances. This control scheme has a better fault-tolerant capability for sensor faults and bounded disturbances than using regular NDI control.
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