We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.

Sub-15 nm-wide gratings with a high aspect ratio of up to 16:1 were fabricated using roll-to-roll nanoimprinting and plasma trimming to achieve high optical performance (up to 12 000:1 extinction ratio with an average transmittance of 82%) and low colour shift (transmittance variation less than 3%) flexible wire-grid polarizers for display applications. We applied two imprint platforms onto glass and plastic substrates to identify the optical properties and characteristics of each fabrication process. To enhance the tolerance, reproducibility, and optical performance of the process, the grating profile symmetry and varying residual layer thicknesses were precisely simulated and controlled to achieve the design targets.

Efficiency of liquid crystal displays highly depends on the amount of polarized light emerging from the backlight module. In this paper, a backlight architecture using a nanoimprint wire grid polarizer for polarization recycling is proposed and studied, in which the extraction efficiency of polarized light is the major concern. The backlight module is composed of the stack of a wire grid polarizer, a lenticular array and a light guide plate. The light guide plate features interleaving v-groove and trapezoidal ridge coated with aluminum on the top surface, and scattering dot array on the bottom. The angular divergence of emerging light from the light guide plate can be well constrained so as to exploit the angular range with the best transmission of polarized light for the wire grid polarizer. The prototype of a 2.5-inch module has demonstrated an angular divergence of 48°. The overall extraction efficiency of polarized light enhanced by 21% and uniformity of 76% have been achieved.

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