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Spectacular applications of anaerobic membrane bioreactors (AnMBRs) are emerging due to the membrane enhanced biogas production in the form of renewable bioresources. They produce similar energy derived from the world's depleting natural fossil energy sources while minimizing greenhouse gas (GHG) emissions. During the last decade, many types of AnMBRs have been developed and applied so as to make biogas technology practical and economically viable. Referring to both conventional and advanced configurations, this review presents a comprehensive summary of AnMBRs for biogas production in recent years. The potential of biogas production from AnMBRs cannot be fully exploited, since certain constraints still remain and these cause low methane yield. This paper addresses a detailed assessment on the potential challenges that AnMBRs are encountering, with a major focus on many inhibitory substances and operational dilemmas. The aim is to provide a solid platform for advances in novel AnMBRs applications for optimized biogas production.

Psychiatric disorders such as anxiety and depression precipitated by substance use occurred during both use and withdrawal. Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use disorders (SUDs) and other psychiatric disorders. To better understand the role of exosomal miRNAs in the pathology of symptoms of anxiety and depression in patients with SUDs, we first isolated circulating exosomes from heroin-dependent patients (HDPs) and methamphetamine-dependent patients (MDPs) and identified exosomal miRNAs that were differentially expressed between patients and healthy controls (HCs). Furthermore, the correlations between exosomal DE-miRNAs and symptoms of anxiety and depression which were measured using Hamilton-Anxiety (HAM-A)/Hamilton-Depression (HAM-D) Rating Scales in the participants. Notably, the expression level of exosomal hsa-miR-16-5p, hsa-miR-129-5p, hsa-miR-363-3p, and hsa-miR-92a-3p showed significantly negative correlations with HAM-A scores in both HDPs and MDPs. But all of the 4 DE-miRNAs lost significant correlations with HAM-D scores in HDPs. Functional annotation analyses showed that the target genes of the DE-miRNAs were mainly enriched for “synapse”, “cell adhesion”, “focal adhesion” and “MHC class II protein complex”. Our study suggests that a set of circulating exosomal miRNAs were associated with anxiety and depression in SUD patients and may have clinical utility as diagnostic and prognostic biomarkers.

In recent years, prefabricated housing has become increasingly popular and widely promoted due to its potential to improve the construction environment, quality and productivity. To develop prefabricated housing and address housing challenges, the Chinese government is encouraging prefabricated public housing. Consequently, evaluating the environmental performance of prefabricated public housing to identify whether it is environmentally friendly and worthy of investment is urgently needed. This paper compares the costs and benefits of prefabricated public projects and traditional projects based on a questionnaire and field investigation. The paper introduces information from the collected questionnaires on the respondents and projects in Beijing; this information includes the prefabrication rate, technology application, barriers, and industrial performance. The paper also reports a cost-benefit analysis of the changing rates of construction costs and environmental benefits (energy consumption, water usage, construction waste, steel and concrete usage, dust and noise pollution) by using the ∆B/∆C ratio to show the efficiency of prefabricated housing. The results indicate that the ratio is 1.81, which exceeds 1; therefore, investment in prefabricated public housing is environmentally acceptable and efficient. This paper also discusses the efficiencies in different categories and structures with and without incentives. The results show that the costs are higher and the environmental benefits are efficient but not significant; thus, promoting prefabricated public housing is necessary.

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