Background: Resveratrol (RES), an estrogen analog, is considered as a potential cancer chemopreventive agent. However, it remains unclear how RES is transported into cells. In this study, we observed that Caveolin-1(CAV1) expression can increase the cytotoxic and pro-apoptotic activity of RES in a dose-and time-dependent manner both in vitro and in vivo in a Hepatocellular Carcinoma animal model.
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